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Renal pathology in a mouse model of severe Spinal Muscular Atrophy is associated with downregulation of Glial Cell-Line Derived Neurotrophic Factor (GDNF).
Hum Mol Genet
August 2020
Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Spinal muscular atrophy (SMA) occurs as a result of cell-ubiquitous depletion of the essential survival motor neuron (SMN) protein. Characteristic disease pathology is driven by a particular vulnerability of the ventral motor neurons of the spinal cord to decreased SMN. Perhaps not surprisingly, many other organ systems are also impacted by SMN depletion.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze the MRI and histologic characteristics of the supraspinatus tendon in healthy, nonlame Beagle dogs.
- MRI scans revealed a distinctive trilaminar structure of the tendon, with a thick central layer surrounded by thinner outer margins, and histology confirmed organized collagen in the margins and a unique, water-rich composition in the center.
- The findings suggest that a hyperintense signal on MRI alone is not sufficient for diagnosing supraspinatus tendinosis in dogs, as additional MRI indicators of shoulder joint health are needed for an accurate diagnosis.
Subclinical enthesopathy of extensor digitorum tendon is highly prevalent and associated with clinical and ultrasound alterations of the adjacent fingernails in patients with psoriatic disease.
J Eur Acad Dermatol Venereol
October 2018
Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Background: Nail psoriasis disease is associated with an increased probability of psoriatic arthritis, and its clinical signs may have different correlates with the pathogenesis of adjacent bone destruction and have different prognostic value. Recent publications about psoriasis and nail psoriatic disease describe different ultrasonographic findings but the relationship between these ungueal alterations measured by ultrasonography and the presence of enthesopathy of the extensor digitorum has yet to be discovered.
Objective: To describe which ultrasonographic characteristics of nail psoriasis are associated with the presence of subclinical enthesopathy in patients with PsO and asymptomatic PsA.
Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis.
Joint Bone Spine
December 2017
Department of Rheumatology, Brest University Hospital, 29280 Brest, France; Ultrasound Unit Department, Brest University Hospital, 29280 Brest, France. Electronic address:
Objectives: To detect subclinical entheses and nail abnormalities using gray-scale (GS) and power Doppler ultrasonography (PDUS) between patients with nail psoriasis and those with inverse and scalp psoriasis.
Methods: In this prospective monocentric study, patients with nail, inverse and scalp psoriasis, without psoriatic arthritis or systemic treatment, were included. Clinical evaluation and ultrasonographic assessment of 14 entheses and 12 nails were done by a dermatologist (clinical assessment) and a rheumatologist (ultrasonographic assessment).
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