AI Article Synopsis
- The hypopharynx and cervical esophagus are key areas where squamous cell carcinoma often occurs, typically requiring extensive surgery.
- Despite improvements in surgery over the years, patients still face challenges related to quality of life, especially when combined with laryngectomy for treatment.
- Chemoradiation therapy could potentially reduce the cancer and improve outcomes without significantly impacting quality of life, but the decision between surgery and chemoradiotherapy should prioritze patient preference and available information.
Article Abstract
Hypopharynx and cervical esophagus represent a critical location for a squamous cell carcinoma, a neoplasm that usually requires extensive surgery. Although morbidity and mortality of resection have markedly decreased over the past decade, the major issue in these patients remains quality of life owing to the need for combination with a laryngectomy to provide radical treatment. Chemoradiation therapy has the potential to downstage and even cure the disease without altering quality of life dramatically. Today, in the absence of randomized trials, the choice between surgery and definitive chemoradiotherapy should be based on clear information and the patient's preference. Salvage surgery is feasible and effective in selected patients.
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| http://dx.doi.org/10.1046/j.1442-2050.2001.00163.x | DOI Listing |
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