This review analysed the data about the neuropeptides secreted from the different brain structures. Involvement of the endogenous neuropeptides in synaptic plasticity was tested at the model of long-term potentiation (LTP) as a form of learning and the memory formation. The most of these neuropeptides or their fragments involves in the induction and maintenance of the LTP and provides the transformation of short-term excitability of the neurones into the long-term one. They may be considered as nootropic compounds. It is proposed that the system of peptidergic regulation of neuronal plasticity functionates in the brain and there are a possibility to correct the activity of this system during the different pathology.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Intranasal delivery of a ghrelin mimetic engages the brain ghrelin signalling system in mice.
Endocrinology
January 2025
Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden.
Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor (GHSR), promotes food intake, other feeding behaviours and stimulates growth hormone (GH) release from the pituitary. Growth hormone secretagogues (GHS), such as GHRP-6 and MK-0677, are synthetic GHSR ligands that activate orexigenic Neuropeptide Y neurons that co-express Agouti-Related Peptide (AgRP) in the arcuate nucleus of the hypothalamus when administered systemically. Systemic GHRP-6 also stimulates GH release in humans and rats.
View Article and Find Full Text PDFCocaine-Induced Remodeling of the Rat Brain Peptidome: Quantitative Mass Spectrometry Reveals Anatomically Specific Patterns of Cocaine-Regulated Peptide Changes.
ACS Chem Neurosci
January 2025
School of Pharmacy, University of Wisconsin─Madison, Madison, Wisconsin 53705, United States.
Addiction to psychostimulants, including cocaine, causes widespread morbidity and mortality and is a major threat to global public health. Currently, no pharmacotherapies can successfully treat psychostimulant addiction. The neuroactive effects of cocaine and other psychostimulants have been studied extensively with respect to their modulation of monoamine systems (particularly dopamine); effects on neuropeptide systems have received less attention.
View Article and Find Full Text PDFNeurokinin-1 receptors in the nucleus accumbens shell influence sensitivity to social defeat stress and stress-induced alcohol consumption in male mice.
Addict Neurosci
December 2024
Department of Physiology and Pharmacology, University of Georgia, Athens, GA.
Chronic social defeat stress (SDS) is a widely employed preclinical model of depression involving repeated exposure to physical defeats using a resident-intruder model in male mice. Exposure to SDS induces depressive-like phenotypes including anhedonia, social withdrawal, and increased drug and alcohol consumption. Previously, we found that expression of the neurokinin-1 receptor (NK1R) is increased in the nucleus accumbens (NAC) of mice that are sensitive to this stressor and increase their alcohol intake.
View Article and Find Full Text PDFRole of the medial septum neurotensin receptor 1 in anxiety-like behaviors evoked by emotional stress.
Psychoneuroendocrinology
January 2025
Women and Children's Medical Research Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address:
Anxiety is one of the most common mental disorders. Neurotensin (NT) is a neuropeptide widely distributed in the central nervous system, involved in the pathophysiology of many neural and psychiatric disorders such as anxiety. However, the neural substrates mediating NT's effect on the regulation of anxiety have not been fully identified.
View Article and Find Full Text PDFThe and of Vincent van Gogh: neuropeptides of bondedness and loss.
Front Psychol
December 2024
Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, United States.
We introduce two Korean-named yet transcultural feelings, and , to fill gaps in neuroscientific understanding of mammalian bondedness, loss, and aggression. is a visceral sense of connectedness to a person, place, or thing that may arise after proximity, yet does not require intimacy. The brain opioid theory of social attachment (BOTSA) supports the idea that involves increased activity of enkephalins and beta-endorphins.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!