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Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents.
Mol Divers
January 2025
Department of Pharmaceutics, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
The current research focused on the synthesis of two series of pyrazole derivatives and evaluation of their insecticidal effectiveness. In the first series, seven pyrazole Schiff bases 3a-g were successfully synthesized with yields (79-95%) by condensing phenylfuran-2-carbaldehyde with substituted pyrazole rings. In the second series, eleven amino acid-pyrazole conjugates 6a-k were synthesized utilizing acetic acid, sulfuric acid, morpholine, and EDC.
View Article and Find Full Text PDFOptimal network sizes for most robust Turing patterns.
Sci Rep
January 2025
Department of Life Sciences, Imperial College, London, SW7 2AZ, UK.
Many cellular patterns exhibit a reaction-diffusion component, suggesting that Turing instability may contribute to pattern formation. However, biological gene-regulatory pathways are more complex than simple Turing activator-inhibitor models and generally do not require fine-tuning of parameters as dictated by the Turing conditions. To address these issues, we employ random matrix theory to analyze the Jacobian matrices of larger networks with robust statistical properties.
View Article and Find Full Text PDFInsect frass fertilizer as soil amendment for improved forage and soil health in circular systems.
Sci Rep
January 2025
USDA-ARS Poultry Production and Product Safety Research Unit, Fayetteville, AR, 72701, USA.
Insect farming is expected to increase in coming years, thus generating high quantities of frass (insect excreta). Frass valorization hinges on basic agronomic research prior to industry upscaling. Here, we investigated soil physiochemical properties, SMAF (Soil Management Assessment Framework) soil health, CO efflux, and bermudagrass [Cynodon dactylon (L.
View Article and Find Full Text PDFCalcium hydroxide nanoparticles induce cell death, genomic instability, oxidative stress and apoptotic gene dysregulation on human HepG2 cells.
Sci Rep
January 2025
Faculty of Biotechnology, October University for Modern Sciences and Arts, 6th of October, Egypt.
Calcium hydroxide nanoparticles (Ca(OH)NPs) possess potent antimicrobial activities and unique physical and chemical properties, making them valuable across various fields. However, limited information exists regarding their effects on genomic DNA integrity and their potential to induce apoptosis in normal and cancerous human cell lines. This study thus aimed to evaluate the impact of Ca(OH)NPs on cell viability, genomic DNA integrity, and oxidative stress induction in human normal skin fibroblasts (HSF) and cancerous hepatic (HepG2) cells.
View Article and Find Full Text PDFPrediction of ADMET profile and anti-inflammatory potential of chamuangone.
Sci Rep
January 2025
Faculty of Medical Technology, Prince of Songkla University, Songkhla, 90110, Thailand.
Chamuangone, a compound extracted from the leaves of Garcinia cowa, exhibits various biological activities. Yet, its absorption, distribution, metabolism, excretion, and toxicity (ADMET) profile as well as anti-inflammatory effects in macrophages remain unexplored. In this study, we employed a computational tool to predict the ADMET profile of chamuangone and performed molecular docking simulations to assess its interactions with key proteins involved in inflammatory pathways.
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