1. [14C]Metronidazole was rapidly absorbed from the gastro-intestinal tract of rats giving maximum blood levels of radioactivity, equivalent to 6-4 and 6-7 mug metronidazole per ml blood, 1 h after oral dosing. 2. There was rapid equilibration between blood and most tissues, although radioactivity was concentrated in the liver, kidney, gastro-intestinal tract and vaginal secretions. 3. The half-life of clearance of radioactivity from the majority of tissues was between 3 and 4 h, although it was longer in the skin (8 h) and gastro-intestinal tract (14 h). 4. Fourteen radioactive excretion products were detected in rat urine and all the major products were identified. These all contained a nitro group and represented 97 degrees of the total radioactivity excreted in urine. 5. Unchanged metronidazole was secreted throughout the entire length of the gastro-intestinal tract and into the vagina of rats. 6. A hypothesis has been proposed to explain the high clinical efficacy of metronidazole in treating trichomonal and amoebic infections.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/00498257509052069 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
GUT, VAGINAL AND URINARY MICROBIOTA AS POTENTIAL BIOMARKERS OF SENSITIZATION IN WOMEN WITH CHRONIC PELVIC PAIN.
Am J Obstet Gynecol
January 2025
Nantes University, Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, France.
Background: A subgroup of patients with chronic pelvic pain (CPP) exhibit organ sensitization, whose origin and mechanism remains largely unknown. Changes in microbiota composition in pelvic organs have been found to be associated with various pelvic pathological conditions. Therefore, a comprehensive analysis of the gut and genito-urinary microbiota composition and interactions in women with CPP may be key to understanding their involvement in the sensitization processes.
View Article and Find Full Text PDFAccounting for the role of the gastro-intestinal tract in the ammonia and urea-N dynamics of freshwater rainbow trout on long-term satiation feeding.
J Exp Biol
January 2025
Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
The contribution of the gut to the ingestion, production, absorption, and excretion of the extra ammonia and urea-N associated with feeding ("exogenous" fraction) has received limited prior attention. Analysis of commercial pellet food revealed appreciable concentrations of ammonia and urea-N. Long term satiation-feeding increased whole trout ammonia and urea-N excretion rates by 2.
View Article and Find Full Text PDFDataset for gastrointestinal tract segmentation on serial MRIs for abdominal tumor radiotherapy.
Data Brief
December 2024
Department of Human Oncology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792, USA.
Purpose: Integrated MRI and linear accelerator systems (MR-Linacs) provide superior soft tissue contrast, and the capability of adapting radiotherapy plans to changes in daily anatomy. In this dataset, serial MRIs of the abdomen of patients undergoing radiotherapy were collected and the luminal gastro-intestinal tract was segmented to support an online segmentation algorithm competition. This dataset may be further utilized by radiation oncologists, medical physicists, and data scientists to further improve auto segmentation algorithms.
View Article and Find Full Text PDFMechanism of RBM15 in the malignant proliferation of colorectal cancer cells through regulating the stability of LncRNA FGD5-AS1 via m6A modification.
Exp Cell Res
January 2025
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Shandong First Medical University, Tai 'an, Shandong, 271000, China. Electronic address:
Colorectal cancer (CRC) is the third most prevalent cancer all around the world. This study explored the mechanism of RBM15-mediated m6A modification in CRC cell malignant proliferation. The expression of RBM15, LncRNA FGD5-AS1, and HOXC10 was detected in CRC cells.
View Article and Find Full Text PDFThe Unusual Clinical Presentation of Eosinophilic Gastroenteritis and Its Response to Mepolizumab: Two Case Reports.
Cureus
October 2024
Internal Medicine, Sheikh Shakhbout Medical City, Abu Dhabi, ARE.
Article Synopsis
- * Diagnosis is confirmed through histological examination of the gastrointestinal tract, but the clinical symptoms can vary, making it hard to identify.
- * Two case studies of young males show that early management with steroids and the biologic mepolizumab led to good outcomes, helping to reduce steroid use and achieve symptom remission.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!