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A novel combinatorial approach integrating experimental and computational analysis of antioxidant activity: Evaluating catechin and L-ascorbic acid in serum.
PLoS One
January 2025
Chemistry and Biochemistry, University of St. Thomas, Houston, TX, United States of America.
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality globally, with oxidative stress playing a pivotal role in its progression. Free radicals produced via oxidative stress contribute to lipid peroxidation, leading to subsequent inflammatory responses, which then result in atherosclerosis. Antioxidants inhibit these harmful effects through their reducing ability, thereby preventing oxidative damage.
View Article and Find Full Text PDFVitamin D levels and morbidity and mortality in very low birth weight preterm infants.
Andes Pediatr
August 2023
Departamento de Pediatría, Facultad de Medicina, Universidad de Concepción, Concepción, Chile.
Unlabelled: Very low birth weight (VLBW) preterm newborns lack some nutrients such as vitamin D (VD), which is important in the function and development of different systems.
Objective: To evaluate serum levels of 25-OH-VD in VLBW newborns and to describe the possible association between its deficit and frequent morbidities in this population.
Patients And Methods: Cross-sectional study of VLBW newborns (< 1,500 g and/or < 32 weeks of gestational age).
Unlabelled: Children with chronic respiratory diseases (CRD) are at high risk of vitamin D deficiency, which can be aggravated in those hospitalized for prolonged periods, a group with unknown prevalence.
Objective: to determine the vitamin D status and the risk factors in children with CRD hospitalized for prolonged periods.
Patients And Method: Cross-sectional study carried out at the Hospital Josefina Martinez from September to December 2012, in children with CRD.
Cluster analysis of sarcopenia in older adults: significant factors contributing to disease severity.
Eur Geriatr Med
January 2025
Federal State Autonomous Educational Institution of Higher Education "Russian National Research Medical University named after N.I. Pirogov" of the Ministry of Health of the Russian Federation, Separate structural unit "Russian Gerontology Research and Clinical Centre", 16 1st Leonova Street, Moscow, Russia, 129226.
Introduction: The European Working Group on Sarcopenia in Older People (EWGSOP2) defines sarcopenia as a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age. New findings on the hormonal and metabolic characteristics of patients with sarcopenia have aided in developing more targeted therapeutic strategies. However, treating older patients with sarcopenia still poses a number of challenges.
View Article and Find Full Text PDFThe burden of Alagille syndrome: uncovering the potential of emerging therapeutics - a comprehensive systematic literature review.
J Comp Eff Res
January 2025
Guy's & St Thomas' NHS Foundation Trust, London, UK.
Alagille syndrome (ALGS) is a rare, cholestatic multiorgan disease associated with bile duct paucity, leading to cholestasis. Clinical symptoms of cholestasis include debilitating pruritus, xanthomas, fat-soluble vitamin deficiencies, growth failure, renal disease and impaired health-related quality of life (HRQoL). The main objective was to review the current literature on the epidemiological, clinical, psychosocial and economic burden of ALGS in view of the development of ileal bile acid transporter (IBAT) inhibitors.
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