The unweighting and/or immobilization in the shortened position leads to muscle atrophy, slow-to-fast transformation and biochemical alterations in muscle fibers. This process could be prevented by the stretching or loaded contraction. On the other hand Kozlovskaya et al. demonstrated triggering of postural synergies due to using artificial support simulator in spaceflight. The study was aimed to test if the plantar support stimulation might prevent muscle atrophy, slow-to-fast transformation of muscle fibers and oxidative potential alteration during gravitational unloading.
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Muscle Nerve
January 2025
Department of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
Nucleic Acids Res
January 2025
Institute for Biomedicine and Glycomics, School of Environment and Science, Griffith University, 46 Don Young Road, Brisbane QLD 4111, Australia., Brisbane, QLD 4111, Australia.
While many genetic tools exist for zebrafish, this animal model still lacks robust gene-silencing and microRNA-delivery technologies enabling spatio-temporal control and traceability. We have recently demonstrated that engineered pri-miR backbones can trigger stable gene knockdown and/or express microRNA(s) of choice in this organism. However, this miRNA-expressing technology presents important limitations.
View Article and Find Full Text PDFFront Physiol
January 2025
Department of Muscle and Bone Metabolism, German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany.
[This corrects the article DOI: 10.3389/fphys.2021.
View Article and Find Full Text PDFRenewed scientific interest in sympathetic modulation of muscle and neuromuscular junctions has spurred a flurry of new discoveries with major implications for motor diseases. However, the role sympathetic axons play in the persistent dysfunction that occurs after nerve injuries remains to be explored. Peripheral nerve injuries are common and lead to motor, sensory, and autonomic deficits that result in lifelong disabilities.
View Article and Find Full Text PDFBrain Behav
January 2025
Department of Pediatric Neurology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey.
Background: Spinal muscular atrophy (SMA) is a motor neuron disease caused by mutations in the SMN1 gene. Nusinersen, an antisense oligonucleotide, has been shown to improve motor function in SMA patients. However, concerns regarding its renal safety remain as previous studies have linked similar treatments to renal toxicity.
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