The goal of this paper was studying the effectiveness of frequently repeated low values of long duration acceleration on circulatory system response during gradual onset rate of acceleration on a human centrifuge.
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Deep learning-based design and experimental validation of a medicine-like human antibody library.
Brief Bioinform
November 2024
Biotherapeutics Molecule Discovery, Boehringer Ingelheim Pharmaceutical Inc., 900 Ridgebury Road, Ridgefield, CT 06877, United States.
Antibody generation requires the use of one or more time-consuming methods, namely animal immunization, and in vitro display technologies. However, the recent availability of large amounts of antibody sequence and structural data in the public domain along with the advent of generative deep learning algorithms raises the possibility of computationally generating novel antibody sequences with desirable developability attributes. Here, we describe a deep learning model for computationally generating libraries of highly human antibody variable regions whose intrinsic physicochemical properties resemble those of the variable regions of the marketed antibody-based biotherapeutics (medicine-likeness).
View Article and Find Full Text PDFAssessment of heart rate deceleration capacity, heart rate deceleration runs, heart rate acceleration capacity, and lipoprotein-related phospholipase A2 as predictors in individuals with dementia.
Front Neurol
January 2025
Department of Neurology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, China.
Background: Autonomic dysfunction plays an essential role in dementia, however, it is not known whether electrocardiogram autonomic dysfunction-related indicators are associated with the severity of dementia. In this study, we attempted to investigate whether these indicators are correlated in patients with vascular dementia and Alzheimer's disease compared with normal health individuals. For this purpose, we measured and analyzed the predictive value of heart rate deceleration capacity (DC), heart rate deceleration runs (DRs), heart rate acceleration capacity (AC) along with the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2).
View Article and Find Full Text PDFDeep learning enabled rapid classification of yeast species in food by imaging of yeast microcolonies.
Food Res Int
February 2025
Department of Food Science & Technology, University of California-Davis, Davis, CA 95616, USA; Department of Biological & Agricultural Engineering, University of California-Davis, Davis, CA 95616, USA. Electronic address:
Diverse species of yeasts are commonly associated with food and food production environments. The contamination of food products by spoilage yeasts poses significant challenges, leading to quality degradation and food loss. Similarly, the introduction of undesirable strains during fermentation can cause considerable challenges with the quality and progress of the fermentation process.
View Article and Find Full Text PDFMicroscale Spatiotemporal Variation of Reactive Oxygen Species in the Charosphere: Underlying Formation Mechanism and Their Role in CO Emission.
Environ Sci Technol
January 2025
College of Natural Resources and Environment, Northwest A&F University, Yangling 712100, China.
Charosphere, a highly active zone between biochar and surrounding soil, is widely present in agricultural and wildfire-affected soils, yet whether reactive oxygen species (ROS) are produced within the charosphere remains unclear. Herein, the production and spatiotemporal evolution of charosphere ROS were explored. In situ ROS capture visualized a gradual decrease in ROS production with increasing distance from the biochar/soil interface.
View Article and Find Full Text PDFExosome-Like Vesicles from Callus Enhanced Wound Healing by Reducing LPS-Induced Inflammation.
J Microbiol Biotechnol
November 2024
Preclinical Research Center, Daegu Gyeongbuk Medical Innovation Foundation (K-MEDI hub), Daegu 41061, Republic of Korea.
(LE), a medicinal plant from the Boraginaceae family, is traditionally used in East Asia for its therapeutic effects on skin conditions, including infections, inflammation, and wounds. Recently, the role of extracellular vesicles (EVs) as mediators of intercellular communication that regulate inflammation and promote tissue regeneration has garnered increasing attention in the field of regenerative medicine. This study investigates exosome-like vesicles derived from LE callus (LELVs) and their potential in enhancing wound healing.
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