It has been shown earlier that 7-19 day exposure of monkeys to hypokinesia with head-down tilt (HDT) produces osteopenia in their load-bearing bones. The present work continued the investigations of osteopenia dynamics in monkeys which had been under the HDT conditions for 15 and 30 days.
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- Head-down bed rest (HDBR) simulates the effects of weightlessness on the human body, particularly focusing on how it impacts the cardiovascular system over a 21-day period.
- *The study found that HDBR increased levels of various proteins related to cardiovascular diseases and processes like blood clotting and inflammation, suggesting negative effects on heart health.
- *Conversely, some proteins involved in essential functions like oxygen transport and cell structure decreased during the HDBR, indicating overall physiological stress on the body.
Impacts of Microgravity Analogs to Spaceflight on Cerebral Autoregulation.
Front Physiol
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INSERM UMR 1048, Institute of Cardiovascular and Metabolic Diseases (I2MC), Toulouse, France.
It is well known that exposure to microgravity in astronauts leads to a plethora physiological responses such as headward fluid shift, body unloading, and cardiovascular deconditioning. When astronauts return to Earth, some encounter problems related to orthostatic intolerance. An impaired cerebral autoregulation (CA), which could be compromised by the effects of microgravity, has been proposed as one of the mechanisms responsible for orthostatic intolerance.
View Article and Find Full Text PDFIrregular Ventricular Tachycardia as a Mechanism of Stabilization of Mechanoelectrical Processes in Canine Heart under Conditions of Antiorthostatic Hypokinesia.
Bull Exp Biol Med
December 2018
Komi Research Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, Russia.
We studied electrophysiological mechanisms of ventricular arrhythmias in dogs (n=7) under conditions of antiorthostatic hypokinesia (head-down tilt 45°). Abnormal transmural heterogeneity of repolarization in the base and apex of the left ventricle and increased dispersion of myocardial repolarization were revealed. By minute 30 of antiorthostatic hypokinesia, an increase in the duration of repolarization was revealed after a period of ventricular arrhythmia in all segments and regions of heart ventricles, which was accompanied by impairment of the pumping function of the heart.
View Article and Find Full Text PDFRepolarization of Heart Ventricles in Dogs during Recovery after Antiorthostatic Hypokinesia.
Bull Exp Biol Med
June 2016
Institute of Physiology, Komi Research Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia.
Repolarization properties of ventricular myocardium were studied in anesthetized adult dogs of both sexes subjected to antiorthostatic hypokinesia (head-down tilt at 45° and 60° to the horizontal) and during recovery period (horizontal position for 15 min). The time of repolarization of ventricular myocardium during recovery surpassed the initial value, which represents an adaptive response of the heart to antiorthostasis.
View Article and Find Full Text PDFEffect of Simulated Microgravity and Lunar Gravity on Human Inspiratory Muscle Function: 'Selena-T' 2015 Study.
Adv Exp Med Biol
June 2017
Research Institute for Space Medicine of Federal Research Clinical Center of Specialized Types of Medical Care and Medical Technologies of Federal Biomedical Agency of Russia, 28 Orechovy Boulevard, Moscow, 115682, Russia.
As a part of the multi-disciplinary "SELENA-T"-2015 Bed Rest Study, we investigated the pattern of inspiratory muscles fatigue in 22 healthy male subjects during incremental exercise test to exhaustion before and after 21 days of hypokinesia evoked by bed rest. Hypokinesia consisted of head-down bed rest (HDBR) at a minus 6° angle, simulating microgravity present on orbiting spacecraft, in 10 subjects. The remaining 12 subjects spent the first 5 days of hypokinesia in HDBR position and the subsequent 16 days in head-up bed rest (HUBR) at a plus 9.
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