From elements formed in interstellar furnaces to humans peering back at the stars, the evolution of life has been a long, intricate and perhaps inevitable process. Life as we know it requires a planet orbiting a star at just the right distance so that water can exist in liquid form. It needs a rich supply of chemicals and energy sources. On Earth, the combination of chemistry and energy generated molecules that evolved ways of replicating themselves and of passing information from one generation to the next. Thus, the thread of life began. This chart traces the thread, maintained by DNA molecules for much of its history, as it weaves its way through the primitive oceans, gaining strength and diversity along the way. Organisms eventually moved onto the land, where advanced forms, including humans, ultimately arose. Finally, assisted by a technology of its own making, life has reached back out into space to understand its own origins, to expand into new realms, and to seek other living threads in the cosmos.
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Acc Chem Res
January 2025
Astrophysics Group, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.
ConspectusOrigin of Life research is a fast growing field of study with each year bringing new breakthroughs. Recent discoveries include novel syntheses of life's building blocks, mechanisms of activation and interaction between molecules, and newly identified environments that provide promising conditions for these syntheses and mechanisms. Even with these new findings, firmly grounded in rigorous laboratory experiments, researchers often find themselves uncertain about how to apply them.
View Article and Find Full Text PDFDev Cell
December 2024
Centre for Life's Origins and Evolution, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. Electronic address:
Oscillatory phenomena play widespread roles in the control of biological systems. In D. discoideum, oscillatory cyclic adenosine monophosphate (cAMP) signaling drives collective behavior and induces a temporal developmental gene expression program.
View Article and Find Full Text PDFBiophys Rev
October 2024
Space Science Center (ANGKASA), Institute of Climate Change, National University of Malaysia, 43600 Selangor, Malaysia.
The sun generates light and heat for life on Earth to flourish. However, during the late Hadean-early Archean epoch on Earth, the "faint young sun" (FYS) was less luminous, influencing prebiotic chemistry and, by extension, the origins of life (OoL). However, higher levels of ultraviolet (UV) radiation from the FYS, especially UV-C, due to the lack of an ozone layer, would likely have impacted the assembly, stability, persistence, and functions of prebiotic cellular precursors, i.
View Article and Find Full Text PDFPLoS Biol
November 2024
Center for Mechanisms of Evolution, School of Life Sciences, Arizona State University, Tempe, Arizona, United States of America.
Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. A key challenge relevant to the question of eukaryogenesis is reconstructing the gene repertoire of the last eukaryotic common ancestor (LECA). As data sets grow, sketching an accurate genomics-informed picture of early eukaryotic cellular complexity requires provision of analytical resources and a commitment to data sharing.
View Article and Find Full Text PDFNano Lett
December 2024
Materials Science and Engineering Program, Texas Materials Institute, The University of Texas at Austin, Austin, Texas 78712, United States.
In exploring the genesis of life, liquid-liquid phase-separated coacervate droplets have been proposed as primitive protocells. Within the hydrothermal hypothesis, these droplets would emerge from molecule-rich hot fluids and thus be subjected to temperature gradients. Investigating their thermophoretic behavior can provide insights into protocell footprints in thermal landscapes, advancing our understanding of life's origins.
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