This paper presents the set of specific problems in manned Mars mission, connected with human factor, and scientific approaches for their resolution. The concept of multifunctional medical Complex for Martian spacecraft is discussed.
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| http://dx.doi.org/10.1016/0273-1177(92)90295-9 | DOI Listing |
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Exploring the Users' Perspective of the Nationwide Self-Exclusion Service for Gambling Disorder, "Spelpaus": Qualitative Interview Study.
JMIR Hum Factors
January 2025
Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
Background: Problem gambling and gambling disorder cause severe social, psychiatric, and financial consequences, and voluntary self-exclusion is a common harm reduction tool used by individuals with gambling problems.
Objective: The aim of this study was to explore users' experience of a novel nationwide, multioperator gambling self-exclusion service, "Spelpaus," in Sweden and to inform stakeholders and policy makers in order to improve harm reduction tools against gambling problems.
Methods: Semistructured interviews were conducted with 15 individuals who reported self-perceived gambling problems and who had experience of having used the self-exclusion service Spelpaus in Sweden.
Emphasis on Financial vs Nonfinancial Criteria in Employer Benefits' Measurements.
JAMA Health Forum
January 2025
School of Medicine, Graduate School of Business, Stanford University, Stanford, California.
Importance: Few studies have examined the extent to which employers emphasize financial over nonfinancial criteria in measurement, reporting, and decision-making about health care benefits.
Objective: To measure and identify factors associated with financial over nonfinancial emphasis in employer decision-making about health benefits.
Design, Setting, And Participants: A survey was administered to a nationally representative sample of US employers to assess the extent of employers' emphasis on benefits plans' costs over member experience, access to care, and equity, and on financial vs other considerations when choosing third-party benefits administrators.
Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells.
Invest Ophthalmol Vis Sci
January 2025
Institute of Ophthalmology, School of Medicine, Jinan University, Guangzhou, China.
Purpose: To investigate the therapeutic efficacy of BEZ235, a dual PI3K/mTOR inhibitor, in suppressing pathological neovascularization in an oxygen-induced retinopathy (OIR) mouse model and explore the role of cyclin D1 in endothelial cell cycle regulation.
Methods: Single-cell RNA sequencing was performed to analyze gene expression and cell-cycle alterations in retinal endothelial cells under normoxic and OIR conditions. The effects of BEZ235 on human umbilical vein endothelial cells (HUVECs) and human retinal microvascular endothelial cells (HRMECs) were evaluated by assessing cell viability, cell-cycle progression, proliferation, migration, and tube formation.
Evolving racial/ethnic disparities in AML survival in the novel therapy era.
Blood Adv
February 2025
Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA.
Little is known about the impact of recent advances in acute myeloid leukemia (AML) treatment on racial/ethnic disparities in survival outcomes. We performed a retrospective cohort study of patients with newly diagnosed AML using data from a nationwide electronic health record-derived deidentified database. Patients were categorized based on their diagnosis date relative to venetoclax approval, as pre-novel therapy era (Pre era; 2014-2018; n = 2998) or post-novel therapy era (Post era; 2019-2022; n = 2098).
View Article and Find Full Text PDFUltraprocessed Food Consumption and Obesity Development in Canadian Children.
JAMA Netw Open
January 2025
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
Importance: Ultraprocessed foods (UPF), characterized as shelf-stable but nutritionally imbalanced foods, pose a public health crisis worldwide. In adults, UPF consumption is associated with increased obesity risk, but findings among children are inconsistent.
Objectives: To examine the associations among UPF intake, anthropometric adiposity indicators, and obesity status in Canadian children.
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