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A Digital Tool for Clinical Evidence-Driven Guideline Development by Studying Properties of Trial Eligible and Ineligible Populations: Development and Usability Study.
J Med Internet Res
January 2025
Advanced Care Research Centre, Usher Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Background: Clinical guideline development preferentially relies on evidence from randomized controlled trials (RCTs). RCTs are gold-standard methods to evaluate the efficacy of treatments with the highest internal validity but limited external validity, in the sense that their findings may not always be applicable to or generalizable to clinical populations or population characteristics. The external validity of RCTs for the clinical population is constrained by the lack of tailored epidemiological data analysis designed for this purpose due to data governance, consistency of disease or condition definitions, and reduplicated effort in analysis code.
View Article and Find Full Text PDFAn intelligent controlled spatiotemporal mode-locked (STML) fiber laser based on a photonic lantern (PL) is proposed and experimentally demonstrated. A pair of in-house developed PLs is spliced into the cavity in a back-to-back structure. This PL-based structure functions as a mode multiplexer/demultiplexer to generate higher-order spatial modes.
View Article and Find Full Text PDFAdapting self-measured blood pressure monitoring to reduce health disparities (ASPIRE): a pilot hybrid effectiveness‑implementation study protocol.
Pilot Feasibility Stud
January 2025
Advocate Christ Medical Center, Advocate Health, Oak Lawn, IL, USA.
Background: Hypertension is the leading risk factor for cardiovascular disease (CVD). Despite advances in blood pressure management, significant racial and ethnic disparities persist, resulting in higher risks of stroke, heart disease, and mortality among non-White populations. Self-measured blood pressure (SMBP) monitoring, also known as home blood pressure monitoring, has shown promise in improving blood pressure control, especially when combined with feedback from healthcare providers.
View Article and Find Full Text PDF"They knew the same struggles": perceptions of a group coping skills intervention in patients with chronic graft-versus-host disease.
Support Care Cancer
January 2025
Massachusetts General Hospital, Boston, MA, USA.
Purpose: Chronic graft-versus-host-disease (cGVHD), an inflammatory condition affecting allogeneic hematopoietic cell transplantation (HCT) survivors, is associated with a range of debilitating physical and psychological sequela. Yet HCT recipients with cGVHD are virtually absent from survivorship intervention research. We conducted a randomized clinical trial to evaluate the feasibility and preliminary efficacy of a multidisciplinary group coping skills intervention (Horizons) tailored to meet these patients' unique needs.
View Article and Find Full Text PDFA Pilot Randomized Controlled Trial of a Single-Session Intervention to Reduce Training Psychologists' Burnout.
Behav Ther
January 2025
Feinberg School of Medicine, Northwestern University.
Professional psychology trainees often experience burnout during their clinical training. In a pilot randomized controlled trial, we tested the feasibility, acceptability, utility, and preliminary efficacy of a 10-minute, online single-session intervention (SSI), designed to address burnout, hopelessness, and perceived agency in psychology trainees. In March 2023, 151 doctoral students with symptoms of stress or burnout in accredited, U.
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