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Increased S. aureus colonization and reduced antimicrobial peptide expression in erythrodermic psoriasis.
Int Immunopharmacol
January 2024
Department of Dermatology, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, PR China; Department of Dermatology, The Eighth Affiliated Hospital of Sun Yat-sen University, Guangdong Province, PR China. Electronic address:
Background: Erythrodermic psoriasis (EP) is a severe and rare condition characterized by prominent erythema and scaling over 75 % of the body surface area. Unlike psoriasis vulgaris (PV), EP carries high risk of systemic involvement, including superficial skin infections and sepsis, particularly those caused by Staphylococcus aureus.
Objective: To explore the microecological characteristics of EP and detect the levels of antimicrobial peptides (AMPs) in both skin and serum of EP patients.
What's childhood asthma in French Guiana? A cohort study based on children referred for allergology consultations at the Cayenne hospital center.
Front Public Health
September 2023
Department de Pediatrie, Hôpital de Cayenne "Andrée Rosemon", Cayenne, French Guiana.
Background: Asthma is a multifactorial chronic disease, whose most frequent etiology is allergy, especially to . In French Guiana, the childhood prevalence of Blomia T sensitization is unkwown. The aim of this study was to determine the proportion of sensitization to Blomia T and other mites in asthmatic children, and to describe the characteristics of childhood asthma in French Guiana.
View Article and Find Full Text PDFLipidomics and Metabolomics in Infant Atopic Dermatitis: What's the Correlation with Early Nutrition?
Curr Pediatr Rev
August 2024
Department of Surgical Sciences, University of Cagliari and Neonatal Intensive Care Unit, AOU Cagliari, Cagliari, Italy.
To date, the complex picture of atopic dermatitis (AD) has not yet been fully clarified, despite the important prevalence of this disease in the pediatric population (20%) and the possibility of persistence into adulthood, with important implications for the quality of life of those affected, as well as significant social and financial costs. The most recent scientific evidence suggests a new interpretation of AD, highlighting the important role of the environment, particularly that of nutrition in the early stages of development. In fact, the new indications seem to point out the harmful effect of elimination diets, except in rare cases, the uselessness of chrono-insertions during complementary feeding and some benefits, albeit weak, of breastfeeding in those at greater risk.
View Article and Find Full Text PDF[Allergology: what's new in 2022].
Rev Med Suisse
February 2023
Division d'immunologie et d'allergologie, Service d'immunologie et d'allergologie, Hôpitaux universitaires de Genève et Faculté de médecine, Université de Genève, 1211 Genève 4.
The study of reactions to SARS-CoV-2 vaccines has marked a large part of the literature in the last two years, using the basophil activation test (BAT) as a potential diagnostic tool for reactions to Covid-19 vaccines. In allergic rhinoconjunctivitis, lirentelimab (a humanised monoclonal antibody against lectin 8), reduces patients' symptoms and atopic comorbidities. In severe asthma, tezepelumab (human monoclonal antibody) reduces the annual asthma exacerbation rate over 52 weeks.
View Article and Find Full Text PDFWhat's New in Topicals for Atopic Dermatitis?
Am J Clin Dermatol
September 2022
Division of Pediatric and Adolescent Dermatology, University of California, San Diego and Rady Children's Hospital, San Diego, CA, USA.
Atopic dermatitis (AD) is a chronic inflammatory skin condition that can have tremendous impact on quality of life for affected children and adults. First-line therapy for acute management of AD includes topical therapies such as corticosteroids, calcineurin inhibitors, and, more recently, the phosphodiesterase inhibitor crisaborole. Topical agents have remained the mainstay therapy for decades; however, there has been a longstanding need for topical therapies with high efficacy and low risk of adverse effects with long-term use.
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