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Music moves: Ettlingen dementia study - a pragmatic randomised controlled trial.
Aging Ment Health
January 2025
Institute for Applied Social Sciences, Cener Health, Music Therapy Lab, Technical University of Applied Social Sciences Würzburg-Schweinfurt, Würzburg, Germany.
Objectives: Due to the limited effectiveness of pharmacological treatment, there is a growing need to explore non-pharmacological psychosocial interventions such as music therapy when treating the behavioural and psychological symptoms of dementia (BPSD).
Method: We randomised 57 nursing home residents into individual active music therapy plus standard care (aMT), individual receptive music therapy with tactile sound vibration plus standard care (rMT), or the standard care control group (CG). A trained music therapist provided 12 sessions over 6 weeks.
Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice.
Biol Sex Differ
January 2025
Department of Neurosurgery, Neurosurgery Research Institute, Institute of Neurology, Fujian Provincial Institutes of Brain Disorders and Brain Sciences, The First Affiliated Hospital, Binhai Branch of National Regional Medical Center, Fujian Medical University, Fuzhou, Fujian, 350005, China.
Background: Apolipoprotein E4 (ApoE4) is associated with an increased risk of Alzheimer's disease (AD), depression, and anxiety, which were reported to improve after the administration of metformin. However, sex influence on the effect of ApoE4 and metformin on cognition and mental health is poorly understood.
Methods: ApoE3-TR and apoE4-TR mice of both sexes were randomly assigned to the normal saline and metformin groups from 13 months to 18 months of age.
Suggestions for the decision making in subjective cognitive complaints.
Aging Clin Exp Res
January 2025
Dipartimento di Psicologia dello Sviluppo e della Socializzazione, Università di Padova, Padova, Italy.
In recent years, the increasing life expectancy has underscored the importance of cognitive health alongside physical well-being, particularly because healthy adults may report subjective cognitive complaints (SCC), often related to memory. These complaints may or may not align with objective cognitive impairments, fueling ongoing debates about whether SCC could serve as an early indicator of dementia. While some studies suggest SCC as a potential precursor to dementia, others propose that these complaints may merely co-occur with cognitive decline.
View Article and Find Full Text PDFSex-modulated association between thyroid stimulating hormone and informant-perceived anxiety in non-depressed older adults: Prediction models and relevant cutoff value.
Sci Rep
January 2025
Biologie Intégrative et Physiologie - Neurosciences Cellulaires et Intégrées, Faculté des Sciences et Ingénierie, Sorbonne Université, Paris, France.
The aim of this study was to assess the association between thyroid function and perceived anxiety in non-depressed older adults. Non-depressed Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with complete Thyroid Stimulating Hormone (TSH) and neuropsychiatric inventory (NPI/NPI-Q) were included. The association between anxiety and thyroid function was assessed by logistic regression and sex stratification.
View Article and Find Full Text PDFAutoimmune encephalitis: recovery, residual symptoms and predictors of long-term sequelae.
J Neurol Neurosurg Psychiatry
January 2025
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
Background: Data regarding long-term recovery from autoimmune encephalitis (AE) remain limited.
Methods: This retrospective observational study investigated outcomes in 182 patients who met the 2016 criteria for definite AE. Recovery data were available in 172 patients.
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