Current surveillance methods for detecting recurrence after apparently curative colorectal cancer resection are insensitive and have not been shown to significantly improve survival. New surveillance methods based on molecular, flow cytometric and immunohistochemical detection of small numbers of tumour cells may prove more sensitive in detecting early recurrent cancer and may improve outcome.
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http://dx.doi.org/10.12968/hosp.2001.62.8.1626 | DOI Listing |
J Surg Oncol
January 2025
Department of Surgery, Los Angeles General Medical Center, Los Angeles, California, USA.
J Surg Oncol
January 2025
Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, and Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Background And Objectives: Identification of colorectal cancer (CRC) patients at high risk of recurrence could be of substantial clinical use. We evaluated the association of ctDNA status, using a tumor-informed assay, with recurrence-free survival (RFS).
Methods: Stage III CRC patients were enrolled between 2016 and 2020.
Mol Cancer
January 2025
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Cell Biochem Biophys
January 2025
Department of Food Science, Faculty of Agriculture, Zagazig University, Zagazig, 44519, Egypt.
Inflammatory bowel disease is a collection of intestinal disorders that cause inflammation in the digestive tract. Prolonged inflammation in the gastrointestinal tract is a major risk factor for colorectal cancer. The objective of this study was to fucus on gene expression levels of (KRT-14; associated with epithelial cell integrity) and enhancer of zeste homolog-1 (EZH-2; involved in cellular proliferation) in a IBD rat model in order to rule out impact of nutraceuticals (pumpkin seed oil; PSO) as a complementary approach to conventional treatments of IBD.
View Article and Find Full Text PDFNat Cancer
January 2025
Department of Genetics, Stanford School of Medicine, Stanford, CA, USA.
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