The Wisconsin Cart Sorting Test (WCST) is a well-established measure of executive function. Practical and financial constraints have increased the need for abbreviated neuropsychological procedures. A number of abbreviated versions of the WCST have been introduced and cogent arguments can be made for one over another in certain situations. However, the single deck, 64-card WCST (WCST-64) is the most logical and practical short form. Psychological Assessment Resources (PAR) has recently published a new manual with comprehensive norms for the WCST-64. This paper reviews the new product, discusses the comparability of the WCST-64 and the standard version, and suggests directions for future research.
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http://dx.doi.org/10.1076/clin.15.2.228.1901 | DOI Listing |
Acta Pharmacol Sin
January 2025
National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Sorting nexins (SNXs) as the key regulators of sorting cargo proteins are involved in diverse diseases. SNXs can form the specific reverse vesicle transport complex (SNXs-retromer) with vacuolar protein sortings (VPSs) to sort and modulate recovery and degradation of cargo proteins. Our previous study has shown that SNX3-retromer promotes both STAT3 activation and nuclear translocation in cardiomyocytes, suggesting that SNX3 might be a critical regulator in the heart.
View Article and Find Full Text PDFParkinsonism Relat Disord
December 2024
Department of Neurology and Institute of Neurology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China. Electronic address:
Introduction: The SNP rs2414739 of Vacuolar protein sorting 13 homolog C(VPS13C) gene was identified to be linked with Parkinson's Disease (PD).
Objectives: Explore the clinical progression feature of PD patients with rs2414739 variant.
Methods: Longitudinal data were obtained from the Parkinson's Progression Marker Initiative (PPMI) cohorts.
Alzheimers Dement
December 2024
Barrow Neurological Institute, Phoenix, AZ, USA; Arizona State University, Tempe, AZ, USA.
Background: TDP-43 is an RNA binding protein that is a pathological hallmark of multiple neurodegenerative diseases including Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD). The frequency of observed TDP-43 pathology is estimated at 97% in ALS, 45% in FTD and 40-57% in AD and is characterized by a mislocalization of TDP-43 from the nucleus to the cytoplasm. Indeed, TDP-43 is the third most common proteinopathy in AD, behind only Amyloid beta and Tau.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Background: The gut microbiota and microglia play critical roles in Alzheimer's disease (AD), and more information is needed on how specific bacteria affect brain immunity in AD. We found that Bacteroides increased in aging Tg2576 mice and correlated with amyloid-beta (Aβ) plaques and hypothesized that Bacteroides worsens AD pathology by modulating microglia. Bacteroides is also elevated in AD patients and correlates with cerebrospinal fluid levels of Aβ and tau.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
The Graduate Center, CUNY, New York, NY, USA.
Background: Judgment is an aspect of executive functioning that is critical to many aspects of daily functioning, and often affected in older adults with cognitive decline. The Test of Practical Judgement (TOP-J) evaluates judgment related real-world issues that may arise in aging populations. The current study investigates the incremental validity of the TOP-J-i.
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