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Naso-intestinal versus gastric tube for enteral nutrition in patients undergoing mechanical ventilation: a systematic review and meta-analysis.
Syst Rev
January 2025
Department of Neurosurgery, Pingxiang People's Hospital, Pingxiang, Jiangxi Province, 337000, China.
Background: A systematic appraisal of the comparative efficacy and safety profiles of naso-intestinal tube versus gastric tube feeding in the context of enteral nutrition for mechanically ventilated (MV) patients is imperative. Such an evaluation is essential to inform clinical practice, ensuring that the chosen method of nutritional support is both optimal and safe for this patient population.
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Establishing a GRU-GCN coordination-based prediction model for miRNA-disease associations.
BMC Genom Data
January 2025
Department of Management Information Systems, National Chung Hsing University, Taichung, 402, Taiwan.
Background: miRNAs (microRNAs) are endogenous RNAs with lengths of 18 to 24 nucleotides and play critical roles in gene regulation and disease progression. Although traditional wet-lab experiments provide direct evidence for miRNA-disease associations, they are often time-consuming and complicated to analyze by current bioinformatics tools. In recent years, machine learning (ML) and deep learning (DL) techniques are powerful tools to analyze large-scale biological data.
View Article and Find Full Text PDFIdentification, seasonal prevalence, and preferred attachment sites of ixodid tick species infesting cattle in four municipalities of the province of Tiaret, northwest Algeria.
Exp Appl Acarol
January 2025
Laboratory of Pharmacognosy and Api-Phytothérapy, Mostaganem, Algeria.
Ixodid ticks are important disease vectors that significantly impact animal health and cause considerable economic losses, particularly in tropical and subtropical countries. The aim of the present study was to determine the identity, seasonal distribution, and preferred attachment sites of adult ixodid tick species of cattle in four municipalities (Aïn El Hadid, Sidi Bakhti, Mechraa Safa, and Sidi Hosni) of the Province of Tiaret (north-west Algeria) between May 2022 and May 2023. A total of 317 cattle were randomly selected and examined for tick infestation; 108 (34.
View Article and Find Full Text PDFA note on using random starting values in small sample SEM.
Behav Res Methods
January 2025
Department of Data Analysis, Ghent University, Henri Dunantlaan 1, 9000, Ghent, Belgium.
Model estimation for SEM analyses in commonly used software typically involves iterative optimization procedures, which can lead to nonconvergence issues. In this paper, we propose using random starting values as an alternative to the current default strategies. By drawing from uniform distributions within data-driven lower and upper bounds (see De Jonckere et al.
View Article and Find Full Text PDFIn vivo base editing extends lifespan of a humanized mouse model of prion disease.
Nat Med
January 2025
Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Prion disease is a fatal neurodegenerative disease caused by the misfolding of prion protein (PrP) encoded by the PRNP gene. While there is currently no cure for the disease, depleting PrP in the brain is an established strategy to prevent or stall templated misfolding of PrP. Here we developed in vivo cytosine and adenine base strategies delivered by adeno-associated viruses to permanently modify the PRNP locus to achieve PrP knockdown in the mouse brain.
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