Aim: To study basic parameters of hemostasis in the course of acute poststreptococcal glomerulonephritis (APSGN).
Material And Methods: Platelets number and aggregation 4-platelet factor, Willebrand's factor, activated partial thromboplatelet time, antithrombin III, fibrin-monomeric complexes and products of degradation fibrinogen/fibrin were studied in 127 APSGN patients. Autocoagulation, prothrombin and thrombin tests were made.
Results: Progredient thrombinemia, stable elevation of Willebrand's factor, high aggregation activity of platelets and content of their degradation products evidence for intrarenal microthrombogenesis in APSGN, confirms direct involvement of platelet hemostasis in long-term inflammation in this disease.
Conclusion: Mechanisms of APSGN development operate also through changes in hemostatic system.
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