[Effects of different variants of low-protein diet on progression of chronic renal failure and indices of nutritional status in predialysis stage].

Aim: To investigate effects of different variants of low-protein diet (LPD) (standard and with soy bean protein isolates) on inhibition of chronic renal failure (CRF) progression and prevention of protein-energy insufficiency in predialysis patients.

Materials And Methods: 150 patients with CRF were divided into three groups 50 patients each. Group 1 patients were given combined LPD with addition of soy bean isolate (0.4 g of protein per 1 kg of recommended body mass a day with standard diet and 0.2 g/kg with protein isolate SUPRO 760). Group 2 patients were given standard LPD without additives (0.6 g/kg a day). Patients of group 3 received free diet. All the patients were normally supplied with energy (at least 30-35 kcal/day). In the course of 26 months, clinical, laboratory, anthropometric, expected and functional parameters were measured each 4 months.

Results: Progression of CRF inhibited in patients with restricted protein provision. LPD had no negative effect on laboratory indices. Soy bean isolate LPD was more effective in inhibition of the disease progression than the standard one.

Conclusion: LPD can be used for a long time for inhibition of the progression of CRF provided energy requirements are met. LPD with food additives (soya bean protein isolates) hold perspective for correction of metabolic disorders.