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Assessing Non-Oral PrEP Alternatives Among Young Black Women in the Southern USA.
J Racial Ethn Health Disparities
January 2025
Division of HIV Prevention, Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, 1600 Clifton Road NE, Mailstop US8-4, Atlanta, GA, 30333, USA.
Young Black women in the southern US face a high HIV burden. While daily oral HIV pre-exposure prophylaxis (PrEP) can effectively prevent HIV, its use is low among Black women. The acceptability of and perceived intention to use emerging PrEP products among young Black women in the southern US are not well understood.
View Article and Find Full Text PDFKnowledge of contraceptive methods among deaf women: a qualitative study.
Eur J Contracept Reprod Health Care
December 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, University of São Paulo, Osasco, São Paulo, Brazil.
Objective: To analyse the understanding of deaf women regarding contraceptive methods.
Method: We conducted a qualitative descriptive study in two referral centres for sexual and reproductive health (SRH) in São Paulo, Brazil, trough years 2020-2022. Twenty-eight deaf women who use Brazilian Sign Language (LIBRAS) were interviewed face-to-face and remotely via videocall using a semi-structured questionnaire containing sociodemographic and clinical data and questions about understanding and knowledge of contraceptive methods.
Empowering Arthritis Patients: Optimized Drug Delivery through Piroxicam Microcapsule-Embedded Scaffold Implants via Box-Behnken Experimental Design.
Pharm Nanotechnol
December 2024
Department of Pharmaceutics, SRM College of Pharmacy, SRMIST, Kattankulathur-603203, Tamil Nadu, India.
Background: The necessity for extended drug discharge to alleviate pain without adverse effects underscores the importance of innovative drug delivery systems. Achieving sustained pain relief without compromising patient safety is a critical objective in healthcare. By extending the duration of drug action while suppressing side effects, such systems offer enhanced therapeutic outcomes and improved patient quality of life.
View Article and Find Full Text PDFEstrogen, progestin, and beyond: thrombotic risk and contraceptive choices.
Hematology Am Soc Hematol Educ Program
December 2024
Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Hormonal contraceptive therapy (estrogens and/or progestogens) includes different formulations associated with varying venous thromboembolism (VTE) risks. The thrombogenicity of combined hormonal contraceptives (CHCs) is due at least in part to multiple changes in clotting factors and the vasculature and is dependent on both estrogen dose and type of progestin. Transdermal patch and vaginal ring users have similar or higher VTE risk as combined oral contraceptive users.
View Article and Find Full Text PDFReduced 17β-estradiol following ovariectomy induces mitochondrial dysfunction and degradation of synaptic proteins in the entorhinal cortex.
Neuroscience
January 2025
Department of Psychology, Concordia University, Montreal, Canada. Electronic address:
Article Synopsis
- Reductions in estrogen can lead to cognitive decline by impairing mitochondrial function in the hippocampus, particularly affecting the entorhinal cortex.
- Female rats underwent various procedures to assess the impact of estrogen deficiency, with findings showing that mitochondrial respiration decreased four weeks after ovariectomy but was maintained with estrogen supplementation.
- The study revealed that the absence of estrogen leads to oxidative stress and reduced expression of important mitochondrial and synaptic proteins, suggesting a connection between low estrogen levels and declining cognitive functions.
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