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Glutathione, Vitamin C, and Cysteine Use in Autistic Children With Disruptive Behavior: A Double-Blind, Placebo-Controlled Crossover Pilot Study.
J Dev Behav Pediatr
January 2025
Department of Pediatrics and Norton Children's Research Institute, School of Medicine, University of Louisville, Louisville, KY.
Objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social communication differences and restricted interests. One proposed biologic mechanism underlying ASD is oxidative stress, leading to the clinical use of glutathione based on anecdotal reports of improved behavior in autistic children. In this pilot study, we tested this observation using a randomized clinical trial format to collect preliminary data on glutathione safety and efficacy.
View Article and Find Full Text PDFPromoting playfulness through a play-based occupational therapy intervention: A study protocol.
Afr J Disabil
December 2024
Department of Occupational Therapy, Faculty of Medicine and Health Science, Stellenbosch University, Cape Town, South Africa.
Background: Play is integral to optimal childhood development. Occupational therapists often use play to improve play skills. However, when it comes to learners with autism spectrum disorder (ASD) in South Africa, there is limited research regarding play-based interventions that address the underlying motivators of play, namely, social play and playfulness.
View Article and Find Full Text PDFDifferential Relations Between Parenting and Emotion Regulation in Children with ASD Across Dyadic and Independent Contexts.
J Autism Dev Disord
January 2025
Department of Psychological Science and Claremont Autism Center, Claremont Mckenna College, Claremont, CA, USA.
Many children with ASD exhibit difficulties with emotion regulation that greatly impair functioning. Certain intrinsic correlates of dysregulation have been identified in this population, but the search for potential environmental influences has been less fruitful. The current study examined several aspects of parenting as correlates of observed regulation in Autistic children, as measured in both parent-child and independent regulatory contexts.
View Article and Find Full Text PDFA Concurrent Validity Study of the Mullen Scales of Early Learning (MSEL) and the MacArthur-Bates Communicative Developmental Inventory (CDI) in Infants with an Elevated Likelihood or Diagnosis of Autism.
J Autism Dev Disord
January 2025
Faculty of Psychology, University of Warsaw, Warsaw, Poland.
Infants at elevated likelihood for or later diagnosed with autism typically have smaller vocabularies than their peers, as shown by the Mullen Scales of Early Learning (MSEL) and the MacArthur-Bates Communicative Developmental Inventory (CDI). However, the extent to which MSEL and CDI scores align remains unclear, especially across clinical and non-clinical populations. This study examined whether the concurrent validity of the MSEL and CDI differs based on autism likelihood and diagnosis.
View Article and Find Full Text PDFInvestigating Disembodiment-related Brain Activation by Interaction between Perspective-shifting and the Experience of Agency in Autism Spectrum Disorder: A Possible Relationship with Interoceptive Abilities.
Clin Psychopharmacol Neurosci
February 2025
Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Korea.
Objective: Many studies have explored sense of self in individuals with autism spectrum disorder (ASD); however, few have reported on their experience of "disembodiment." This study aimed to investigate the differences in brain activity between patients with ASD and neurotypicals (NTs) under conditions causing disembodiment and to examine the correlation between their interoceptive abilities and disembodiment-related brain activity.
Methods: 18 Participants with ASD and 21 NTs completed psychological evaluations, interoceptive abilities measurement, and functional magnetic resonance imaging (fMRI).
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