AI Article Synopsis
- - The study analyzed the effectiveness of combined treatment (radiation therapy with or without hypoxia) versus surgical treatment alone in 203 and 200 patients, respectively.
- - Combined treatment groups received either standard radiation (20 Gy) or hypoxyradiotherapy (HRT) with different gas mixtures (HGM-10 and HGM-9) before surgery, while the control group only underwent surgery.
- - Results showed that combined treatment led to higher 5-year survival rates and lower rates of postoperative complications and cancer recurrence compared to surgery alone, particularly in the group with HGM-9 and increased radiation doses.
Article Abstract
Efficacy of combined treatment (203 patients) and surgical treatment (200 patients) alone was analyzed. In combined treatment either radiation therapy (RT) in the dose 20 Gy over 5 days (group 1) or hypoxyradiotherapy (HRT) in the same doses but in combination with hypoxia (10% oxygen and 90% nitrogen--hypoxic gas mixture HGM-10--group 2) were used in preoperative period. In group 3 HGM-9 (9% oxygen and 91% nitrogen) was used as radioprotector in preoperative period but in increased by 25% radiation doses: total 25 Gy, 5 Gy for 5 days. In the control group only radical surgical treatment was performed. Preoperative irradiation didn't increase the rate of postoperative complications. At the same time the 5-year survival rate was higher in all the groups of patients on combined treatment than in the group of patients on surgical radical treatment. In the group with HGM-9 and increased by 25% radiation doses postoperative complications rate was lower, recurrences and distant metastases occurred less frequently.
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