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Role for neurological and immunological resilience in the pathway of the aging muscle powerpenia: InCHIANTI study longitudinal results.
Geroscience
January 2025
Longitudinal Studies Section, Translational Gerontology Branch, National Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
The neuromuscular junction shows several degenerative changes with aging, resulting in a reduction of transmission efficacy. These changes, paired with low-grade chronic inflammation, were considered triggers of the aging muscle processes. The main objective of this study is to assess the role of leukocyte count-derived ratios, nerve conduction velocity (NCV), and compound muscle action potential (CMAP) in determining time-dependent reduction in lower limb muscle explosive strength, a condition that has been defined as powerpenia.
View Article and Find Full Text PDFAlemtuzumab and thrombotic thrombocytopenic purpura: Analysis of an international surveillance database and systematic literature review.
Transfus Apher Sci
January 2025
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Objectives: Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy associated with severe deficiency in ADAMTS13. ADAMTS13 deficiency may be secondary to absent or dysfunctional protein production due to mutations in the ADAMTS13 gene (congenital TTP) or autoantibody-mediated clearance and/or inhibition (immune-mediated TTP). This autoimmunity may, albeit rarely, occur secondary to certain medications (eg, ticlopidine).
View Article and Find Full Text PDFEvaluation of forest eco-efficiency: A transformation of ecological value quantity perspective.
Sci Total Environ
January 2025
China Center for Energy Economics Research, School of Economics, Xiamen University, Fujian, Xiamen 361005, China. Electronic address:
Numerous beneficial products and services are offered by forest ecosystem. However, studies on the efficiency transformation perspective of forest ecological value are relatively few. This study accounts for material supply, ecological service, and cultural value when calculating the gross forest ecological economic product (GFEEP).
View Article and Find Full Text PDFDriver lines for studying associative learning in .
Elife
January 2025
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
The mushroom body (MB) is the center for associative learning in insects. In , intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid the foundation for precise interrogation of the MB neural circuits. However, investigation of many cell types upstream and downstream of the MB has been hindered due to lack of specific driver lines.
View Article and Find Full Text PDFTrends in the incidence and mutational landscape of advanced uterine cancer.
Int J Gynecol Cancer
January 2025
Division of Gynecologic Oncology, California Pacific/Palo Alto/Sutter Health Research Institute, San Francisco, CA, USA.
Objective: The aim of this study was to examine disparities in 20-year incidence trends and mutations in advanced-stage uterine cancer in the United States, given poor survival rates.
Methods: Data were obtained from the United States Cancer Statistics for patients from 2001 to 2019 with International Federation of Gynecology and Obstetrics 2009 stage IVA and IVB uterine cancer. SEER∗Stat 8.
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