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Azacoccones F-H, new flavipin-derived alkaloids from an endophytic fungus Epicoccum nigrum MK214079.
Fitoterapia
October 2020
Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Universitaetsstrasse 1, Geb. 26.23, 40225 Duesseldorf, Germany; Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China. Electronic address:
Three new flavipin-derived alkaloids, azacoccones F-H (1-3), along with six known compounds (4-9) were isolated from the endophytic fungus Epicoccum nigrum MK214079 associated with leaves of Salix sp. The structures of the new compounds were established by analysis of their 1D/2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) data. The absolute configuration of azacoccones F-H (1-3) was determined by comparison of experimental electronic circular dichroism (ECD) data with reported ones and biogenetic considerations.
View Article and Find Full Text PDFDithiodiketopiperazine derivatives from endophytic fungi and .
Nat Prod Res
January 2021
Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Universitaetsstrasse 1, Geb. 26.23, Duesseldorf, Germany.
A new epidithiodiketopiperazine (ETP), pretrichodermamide G (), along with three known (epi)dithiodiketopiparazines () were isolated from cultures of and , endophytic fungi associated with medicinal plants and sp., respectively. The structure of the new compound () was established on the basis of spectroscopic data, including 1D/2D NMR and HRESIMS.
View Article and Find Full Text PDFIsolation, structure elucidation, and antibacterial activity of methiosetin, a tetramic acid from a tropical sooty mold (Capnodium sp.).
J Nat Prod
March 2012
Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, New Jersey 07065, United States.
Drug-resistant bacteria continue to make many existing antibiotic classes ineffective. In order to avoid a future epidemic from drug-resistant bacterial infections, new antibiotics with new modes of action are needed. In an antibiotic screening program for new drug leads with new modes of action using antisense Staphylococcus aureus Fitness Test screening, we discovered a new tetramic acid, methiosetin, from a tropical sooty mold, Capnodium sp.
View Article and Find Full Text PDFEpicorazine C, an antimicrobial metabolite from Stereum hirsutum HKI 0195.
J Antibiot (Tokyo)
June 2001
Hans-Knöll-Institut für Naturstoff-Forschung, Jena, Germany.
Comparison between antifungal and antibacterial activities of several strains of Epicoccum purpurascens from the Mediterranean area.
Mycopathologia
August 1991
Laboratoire de Microbiologie, Faculté des Sciences de Saint Jérôme, Marseille, France.
The antimicrobial activities of seven Epicoccum purpurascens strains isolated either from evergreen oak leaves (Quercus ilex) collected over a period of one year, or from the atmosphere were compared in vitro. Two strains sporulated and conspicuously inhibited the growth of Staphylococcus aureus and Trichophyton mentagrophytes. Thin-layer chromatographic studies showed the existence of some compounds, such as flavipin, which were common to all the strains.
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