Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jo0009393 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sibanin, a novel black fly-derived Kunitz protease inhibitor, prevents thrombus formation in mice by anticoagulation-antiplatelet duality.
Int J Biol Macromol
January 2025
School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, Yunnan, China. Electronic address:
Most Kunitz inhibitors exhibit serine protease inhibitory activity, but limited information is available on the regulation of platelet function. Herein, we report the purification and characterization of a novel single Kunitz domain inhibitor (Sibanin) from the salivary glands of the black fly Simulium bannaense. Recombinant Sibanin prolonged activated partial thromboplastin time and prothrombin time, and exhibited high-affinity binding to FXa and elastase with a KD of 5.
View Article and Find Full Text PDFDiffuse Noxious Inhibitory Controls in Chronic Pain States: Insights from Pre-Clinical Studies.
Int J Mol Sci
January 2025
Instituto de Investigação e Inovação em Saúde da Universidade do Porto-i3S, R. Alfredo Allen 208, 4200-135 Porto, Portugal.
Diffuse noxious inhibitory control (DNIC), also known as conditioned pain modulation (CPM) in humans, is a paradigm wherein the heterotopic application of a noxious stimulus results in the attenuation of another spatially distant noxious input. The pre-clinical and clinical studies show the involvement of several neurochemical systems in DNIC/CPM and point to a major contribution of the noradrenergic, serotonergic, and opioidergic systems. Here, we thoroughly review the latest data on the monoaminergic and opioidergic studies, focusing particularly on pre-clinical models of chronic pain.
View Article and Find Full Text PDFIndividual Rumination in Adult Cancer Care: A Concept Analysis.
Semin Oncol Nurs
January 2025
School of Nursing, Midwifery and Health Systems, University College Dublin (UCD), Dublin, Ireland.
Objective: To conceptualize rumination in adult cancer care.
Methods: Walker and Avant's concept analysis method was used to examine rumination in adults with cancer. A systematic search was conducted across psychology, nursing, medicine, and public health disciplines in PsycINFO, PubMed, Web of Science, CINAHL, and Scopus databases from their inception to April 2024.
Novel antibiotic resistance profiles in bacteria isolated from oil fly larvae Helaeomyia petrolei living in the La Brea Tar Pits.
Antonie Van Leeuwenhoek
December 2024
School of Biological Sciences, University of Nebraska, Lincoln, NE, 68588-0666, USA.
Larvae from the petroleum oil fly, Helaeomyia petrolei, live in the asphaltene and polyaromatic hydrocarbon rich asphalt seeps of Rancho La Brea, Los Angeles, California. These larvae pass high amounts of viscous asphalt through their digestive system, and their gut microbiota is exposed to these extreme conditions. Environmental stress response mechanisms can co-select for antibiotic resistance, and in the current study we used 16S rRNA and genomic sequencing along with the Comprehensive Antibiotic Resistance Database (CARD) tools to characterize antibiotic resistance profiles from six bacteria previously isolated from the oil fly larval intestinal tract, linking phenotypic and genotypic resistance profiles.
View Article and Find Full Text PDFSign, Signifier and Signified in Schrödinger's box.
MethodsX
December 2024
School of Social Sciences and Languages, Vellore Institute of Technology, Vandalur - Kelambakkam Road, Chennai 600127, Tamil Nadu, India.
This study of the article proposes an interdisciplinary approach, integrating quantum mechanics and structuralism to elucidate the complex dynamics of signification. By paralleling the ambiguous nature of subatomic particles with the linguistic system, the study examines the arbitrary relationship between sign, signifier, and signified through quantum principles. Key concepts from quantum mechanics, such as wave-particle duality, superposition, entanglement, and observer effect, are applied to Saussure's theory of signs, revealing intriguing analogies between the two domains.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!