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C286, an orally available retinoic acid receptor β agonist drug, regulates multiple pathways to achieve spinal cord injury repair.
Front Mol Neurosci
August 2024
Neuroscience Drug Discovery Unit, Wolfson Sensory, Pain and Regeneration Centre, King's College London, Guy's Campus, London, United Kingdom.
Retinoic acid receptor β2 (RARβ2) is an emerging therapeutic target for spinal cord injuries (SCIs) with a unique multimodal regenerative effect. We have developed a first-in-class RARβ agonist drug, C286, that modulates neuron-glial pathways to induce functional recovery in a rodent model of sensory root avulsion. Here, using genome-wide and pathway enrichment analysis of avulsed rats' spinal cords, we show that C286 also influences the extracellular milieu (ECM).
View Article and Find Full Text PDFInhibition of astrocytic glycine transporter-1: friend or foe for ameliorating NMDA receptor hypofunction?
Front Cell Neurosci
May 2024
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
Single-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer's disease.
BMC Genomics
May 2024
Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, People's Republic of China.
Background: Alzheimer's disease (AD) is a complicated neurodegenerative disease. Neuron-glial cell interactions are an important but not fully understood process in the progression of AD. We used bioinformatic methods to analyze single-nucleus RNA sequencing (snRNA-seq) data to investigate the cellular and molecular biological processes of AD.
View Article and Find Full Text PDFParticipation of calcium-permeable AMPA receptors in the regulation of epileptiform activity of hippocampal neurons.
Front Synaptic Neurosci
March 2024
Laboratory of Biophysics, Chronobiology and Biomedicine, Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Introduction: Epileptiform activity is the most striking result of hyperexcitation of a group of neurons that can occur in different brain regions and then spread to other sites. Later it was shown that these rhythms have a cellular correlate called paroxysmal depolarization shift (PDS). In 13-15 DIV neuron-glial cell culture, inhibition of the GABA(A) receptors induces bursts of action potential in the form of clasters PDS and oscillations of intracellular Ca concentration ([Ca]).
View Article and Find Full Text PDFGenetic alterations in the neuronal development genes are associated with changes of the tumor immune microenvironment in pancreatic cancer.
Ann Pancreat Cancer
November 2023
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and is highly metastatic. Our prior studies have demonstrated the critical role of axon guidance pathway genes in PDAC and the connection between neuronal development and the tumor microenvironment. A recent study newly identified 20 neuronal development genes [disks large homolog 2 (), neuron-glial-related cell adhesion molecule (), neurexin3 (), mitogen-activated protein kinase 10 (), platelet-derived growth factor D (), protein kinase C epsilon (), potassium calcium-activated channel subfamily M alpha 1 (), polycystic kidney and hepatic disease 1 (), neural cell adhesion molecule 1 (), neuregulin-1 (), zinc finger protein 667 (), cystic fibrosis transmembrane conductance regulator (), acyl-CoA medium-chain synthetase-3 (), complement 6 (), protein tyrosine phosphatase receptor type M (), hypoxia-inducible factor 1 alpha (), adenylyl cyclase 5 (), adherens junctions-associated protein 1 (), neurobeachin (), sodium voltage-gated channel alpha subunit 9 ()] that are associated with perineural invasion and poor prognosis of PDAC.
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