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Potential risk factors of protein aggregation in syringe handling during antibody drug dilution for intravenous administration.
J Pharm Sci
January 2025
Laboratory of Functional Molecular Chemistry, Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
Protein aggregation, a major concern in biopharmaceutical quality control, can be accelerated by various stresses during clinical handling. This study investigated potential aggregation risk factors during dilution process with syringe handling for intravenous administration. Using γ-globulin and IgG solutions as surrogate models of antibody therapeutics, we examined the effects of high sliding speeds and piston operations of the syringe on protein aggregation during saline dilution.
View Article and Find Full Text PDFA randomized control trial to compare Quiet Eye training efficacy to traditional technical training with undergraduate student nurses' peripheral intravenous cannulation performance: a protocol.
Br J Nurs
January 2025
Department of Psychology, Faculty of Arts, University of Calgary, Alberta, Canada; Community Health Sciences, Faculty of Medicine, University of Calgary, Alberta, Canada; Ward of the 21st Century, Cumming School of Medicine, University of Calgary, Alberta, Canada.
Introduction: Peripheral intravenous cannulation (PIVC) is a common and complex procedure with low first-attempt success rates, causing patient suffering and increased healthcare costs. Quiet Eye (QE) training, a gaze-focused approach, has shown promise in improving procedural PIVC skills. We will examine the effectiveness of traditional technical training (TT) and QE training (QET) on student nurse PIVC performance.
View Article and Find Full Text PDFAre ultrasonic tips associated with final irrigation protocols effective in removing biofilms in long oval canals and dentinal tubules?
Clin Oral Investig
January 2025
Department of Restorative Dentistry, Dental Materials, and Endodontics, Bauru School of Dentistry, University of São Paulo, Rua Siqueira Campos, 180, Centro, Vitória da Conquista, Bauru, São Paulo, BA, ZIP: 45.000-455, Brazil.
Objective: This study investigated the associations among endodontic instruments, ultrasonic tips and various final irrigation protocols for removing intracanal and intratubular biofilms in long oval canals.
Methodology: One hundred mandibular premolars inoculated with Enterococcus faecalis were divided into two groups: the control group (CG: n = 10), which received no treatment; and the test groups (n = 30), which included saline (SS), sodium hypochlorite (2.5% NaOCl) and chlorhexidine (2% CHX).
The Pre-Polarization and Concentration of Cells near Micro-Electrodes Using AC Electric Fields Enhances the Electrical Cell Lysis in a Sessile Drop.
Biosensors (Basel)
January 2025
Biomedical Engineering Program, Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA 23508, USA.
Cell lysis is the starting step of many biomedical assays. Electric field-based cell lysis is widely used in many applications, including point-of-care (POC) applications, because it provides an easy one-step solution. Many electric field-based lysis methods utilize micro-electrodes to apply short electric pulses across cells.
View Article and Find Full Text PDFEvaluating the Preventive and Therapeutic Roles of Active Irrigation Systems in Root Canal Treatment: A Narrative Review and Critical Appraisal of Theory and Methodology.
Dent J (Basel)
December 2024
Dental School, University of Seville, 41009 Seville, Spain.
Endodontic therapy aims at preventing or curing apical periodontitis. To conduct this, the cleaning and shaping of the canals are essential. By using an irrigant, such as sodium hypochlorite (NaOCl), practitioners attempt to wash out debris, dissolve organic and inorganic tissue, lubricate the canals, prevent smear layer formation, and disrupt biofilms.
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