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Exercise, hormesis and ageing: a new section in Biogerontology.
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Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Isotschimgine promotes lifespan, healthspan and neuroprotection of Caenorhabditis elegans via the activation of nuclear hormone receptors.
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School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Isotschimgine (ITG) is a bornane-type monoterpenoid derivative naturally occurring in genus Ferula plants and propolis. Its effects on aging and the underlying mechanisms are not yet well understood. This study employed Caenorhabditis elegans (C.
View Article and Find Full Text PDFThe dynamic crosslinking between gut microbiota and inflammation during aging: reviewing the nutritional and hormetic approaches against dysbiosis and inflammaging.
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Department of Biochemistry, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Article Synopsis
- The gut microbiota (GM) plays a crucial role in human health by influencing immune system function and digesting nutrients, with its composition affected by various factors like race and lifestyle.
- Disruptions in GM, known as dysbiosis, can lead to immune dysregulation and contribute to age-related diseases by disrupting intestinal balance.
- Recent research aims to identify the characteristics of a healthy microbiota to inform treatments targeting gut health and preventing diseases associated with microbial imbalances.
The potential of flavonoids to mitigate cellular senescence in cardiovascular disease.
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School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, Jiangsu, People's Republic of China.
Aging is one of the most significant factors affecting cardiovascular health, with cellular senescence being a central hallmark. Senescent cells (SCs) secrete a specific set of signaling molecules known as the senescence-associated secretory phenotype (SASP). The SASP has a remarkable impact on age-associated diseases, particularly cardiovascular diseases (CVD).
View Article and Find Full Text PDFThe potential longevity-promoting hypoxic-hypercapnic environment as a measure for radioprotection.
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The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, 8410501, Beer Sheva, Israel.
Many biological mechanisms of aging well converge with radiation's biological effects. We used scientific insights from the field of aging to establish a novel hypoxic-hypercapnic environment (HHE) concept for radioprotection. According to this concept, HHE which possesses an anti-aging and longevity-promoting potential, should also act as a radiomitigator and radioprotector.
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