We have produced and measured for the first time second harmonic oscillation in the infrared region by a free electron laser. Although such lasing is ideally forbidden, since the gain of a plane wave is zero on axis for an electron beam perfectly aligned with a wiggler, a transverse mode antisymmetry allows sufficient gain in this experiment for lasing to occur. We lased at pulse rates up to 74.85 MHz and could produce over 4.5 W average and 40 kW peak of IR power in a 40 nm FWHM bandwidth at 2925 nm. In agreement with predictions, the source preferentially lased in a TEM01 mode.
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http://dx.doi.org/10.1103/PhysRevLett.87.084801 | DOI Listing |
Sensors (Basel)
January 2025
Institute of Semiconductor Technology (IHT), Technische Universität Braunschweig, Hans-Sommer-Straße 66, 38106 Braunschweig, Germany.
A novel piezoresistive cantilever microprobe (PCM) with an integrated electrothermal or piezoelectric actuator has been designed to replace current commercial PCMs, which require external actuators to perform contact-resonance imaging (CRI) of workpieces and avoid unwanted "forest of peaks" observed at large travel speed in the millimeter-per-second range. Initially, a PCM with integrated resistors for electrothermal actuation (ETA) was designed, built, and tested. Here, the ETA can be performed with a piezoresistive Wheatstone bridge, which converts mechanical strain into electrical signals by boron diffusion in order to simplify the production process.
View Article and Find Full Text PDFSci Rep
January 2025
Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New Area, Shanghai, 201203, China.
A major histologic feature of cirrhosis is the loss of liver architecture with collapse of tissue and vascular changes per unit. We developed qVessel to quantify the arterial density (AD) in liver biopsies with chronic disease of varied etiology and stage. 46 needle liver biopsy samples with chronic hepatitis B (CHB), 48 with primary biliary cholangitis (PBC) and 43 with metabolic dysfunction-associated steatotic liver disease (MASLD) were collected at the Shuguang Hospital.
View Article and Find Full Text PDFActa Biomater
January 2025
Department of Cardiology, Biomedical Engineering, Cardiovascular Institute, Thorax Center, Erasmus MC, Rotterdam, the Netherlands.
Many cardiovascular events are triggered by fibrous cap rupture of an atherosclerotic plaque in arteries. However, cap rupture, including the impact of the cap's structural components, is poorly understood. To obtain better mechanistic insights in a biologically and mechanically controlled environment, we previously developed a tissue-engineered fibrous cap model.
View Article and Find Full Text PDFUltrason Sonochem
January 2025
Acoustic droplet vaporization (ADV) plays a crucial role in ultrasound-related biomedical applications. While previous models have examined the stages of nucleation, growth, and oscillation in isolation, which may limit their ability to fully describe the entire ADV process. To address this, our study developed an integrated model that unifies these three stages of ADV, stimulated by a continuous nonlinear dual-frequency ultrasound wave.
View Article and Find Full Text PDFInflamm Bowel Dis
January 2025
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Background: We previously identified circulating and MRI biomarkers associated with the surgical management of Crohn's disease (CD). Here we tested associations between these biomarkers and ileal resection inflammation and collagen content.
Methods: Fifty CD patients undergoing ileal resection were prospectively enrolled at 4 centers.
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