In the cases of Charcot-Marie-Tooth disease associated with essential tremor so far reported, motor conduction velocity studies strongly suggested that demyelination was a prominent feature of the neuropathy. For the first time two sibs are reported in whom the electrophysiological changes favour axonal degeneration as the main trait of their peripheral neuropathy.
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http://dx.doi.org/10.1159/000114691 | DOI Listing |
J Agric Food Chem
January 2025
Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California 94158, United States.
Pesticides, including insecticides, are indispensable for large-scale agriculture. Modulating chloride ion channels has proven highly successful as a mode of action (MoA) for insect management. Identifying new ligands for these channels affords opportunities for the potential development of new insecticide products.
View Article and Find Full Text PDFPLoS One
January 2025
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Background: Assessing various types of dysfunction in cerebral palsy is a key factor in the treatment and rehabilitation of patients. The objective of this study was to use meta-analysis and systematic review to identify the specific white matter lesions and DTI metrics strongly associated with various types of dysfunction in cerebral palsy.
Methods: We conducted a literature search of PubMed, Embase, Cochrane Library and Web of Science databases to identify trials published that had evaluated the correlation between DTI metrics in sensorimotor pathways and function scores in cerebral palsy.
PLoS One
January 2025
Specialist in Family and Community Medicine, Milladoiro Health Centre, Health Area of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Purpose: To determine the relationship between self-reported physical activity and the components of premorbid metabolic syndrome in patients treated in primary care according to sex.
Methods: Cross-sectional descriptive study conducted on a sample of 2,359 patients without cardiovascular disease or diabetes, included in the cohort of the IBERICAN study. Using ANOVA models and adjusting for age, economic status, employment situation, level of education, adherence to a Mediterranean diet, tobacco use and alcohol consumption, we estimated the association of the variables blood pressure, triglycerides, HDL cholesterol, blood glucose and waist circumference with the self-reported level of physical activity (sedentary, moderate, high, very high).
Sports Med Open
January 2025
GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Avenida República Saharaui s/n, 11519, Puerto Real, Cádiz, Spain.
Background: While there is evidence on the validity and reliability of field-based physical fitness tests in children, adolescents and adults, there is limited evidence to provide feasibility and safety data on the application and performance of the existing field-based physical fitness tests.
Objectives: (i) To examine the feasibility and safety of existing field-based physical fitness tests used in people of all ages and (ii) to establish a comprehensive view of criterion-related validity, reliability, feasibility and safety based on scientific evidence for the existing field-based physical fitness tests in adults.
Methods: The search was conducted through the electronic databases MEDLINE (via PubMed) and Web of Science (all databases) for published studies from inception to 31 January 2023.
J Neurophysiol
February 2025
Neuroscience Program in Psychology, The University of Tennessee, Knoxville, Tennessee, United States.
Buprenorphine is an opioid approved for medication-assisted treatment of opioid use disorder. Used off-label, buprenorphine has been reported to contribute to the clinical management of anxiety. Although human anxiety is a highly prevalent disorder, anxiety is a latent construct that cannot be directly measured.
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