The Tachocomb plates were used by the authors in 15 patients for forming the proximal splenorenal anastomosis and selective decompression of the portal system. The data of sonography have shown the valuable functioning of the shunt in all the patients within the period from 6 months to 3 years. The proposed method provides reliable hemostasis during operation and prevents thrombosis of portosystemic anastomoses.
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Background: VG-3927 is a highly potent, selective, brain penetrant, oral small molecule TREM2 agonist that is currently under development for the treatment of Alzheimer's disease (AD). TREM2, a receptor expressed on microglia in the brain is critical to microglial function in health and in disease. Among microglia-associated AD risk genes, partial loss-of-function variants of TREM2 confer 2-3 fold increase in risk for developing AD, motivating efforts to identify pharmacological agonists targeting TREM2 as a therapeutic option.
View Article and Find Full Text PDFJ Cardiothorac Surg
January 2025
Cerrahpasa Medical Faculty, Department of Cardiovascular Surgery, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Objectives: Despite the advances in medicine, aortic dissection remains a cardiac surgery emergency with high mortality and morbidity rates. This study examined the effects of the Glue + Felt technique, which uses biological glue and felt to repair the proximal anastomotic site, on the outcomes of patients with acute type A aortic dissection.
Methods: A total of 108 patients who underwent surgery for acute type A aortic dissection at our clinic between 2007 and 2020 were included in the study.
BMJ Case Rep
January 2025
Neonatology, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, Maharashtra, India
Arteriovenous malformations (AVMs) are rare congenital vascular malformations with associated morbidities. We describe a neonatal case of upper limb high-flow AVM presenting with upper limb soft tissue mass and postnatal high-output heart failure. Doppler study suggested high-flow AVM, and later magnetic resonance angiography of the right upper limb confirmed the diagnosis.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Umeå Universitet: Umea Universitet, Department of Chemistry, Department of Chemistry, 90187, Umeå, SWEDEN.
Optogenetic systems using photosensitive proteins and chemically induced dimerization/proximity (CID/CIP) approaches enabled by chemical dimerizers (also termed molecular glues), are powerful tools to elucidate the dynamics of biological systems and to dissect complex biological regulatory networks. Here, we report a versatile chemo-optogenetic system using modular, photoswitchable molecular glues (sMGs) that can undergo repeated cycles of optical control to switch protein function on and off. We use molecular dynamics (MD) simulations to rationally design the sMGs and further expand their scope by incorporating different photoswitches, resulting in sMGs with customizable properties.
View Article and Find Full Text PDFLangmuir
January 2025
School of Chemistry and Life Resources, Renmin University of China, 100872 Beijing, China.
Zwitterionic hydrogels exhibit excellent nonfouling and hemocompatibility. However, the practical application of these materials as antifouling coatings for biomedical devices is hindered by several key challenges, including the harsh preparation conditions and the weak coating stability. Here, we present a two-component zwitterionic hydrogel paint for the in situ preparation of robust zwitterionic hydrogel coatings on various substrate surfaces without UV assistance.
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