This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.
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| http://dx.doi.org/10.1016/s0006-8993(01)02617-8 | DOI Listing |
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Article Synopsis
- NMDA receptors, which are activated by glutamate, are essential for learning and memory, and memantine (MEM) is used to manage symptoms in Alzheimer’s but may also have cognitive benefits in healthy individuals.
- A study on male rats tested MEM's effects on working memory through a T-maze task, finding that MEM improved performance, especially in those with initially poorer memory skills.
- Neurochemical analysis revealed that certain protein expressions in brain regions were linked to task performance, indicating that the benefits of MEM could depend on an individual’s baseline working memory capability.
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