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Maintenance of a central high frequency synapse in the absence of synaptic activity.
Front Cell Neurosci
November 2024
Department of Functional Neuroanatomy, Institute of Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.
Activity has long been considered essential for circuit formation and maintenance. This view has recently been challenged by proper synaptogenesis and only mildly affected synapse maintenance in the absence of synaptic activity in forebrain neurons. Here, we investigated whether synaptic activity is necessary for the development and maintenance of the calyx of Held synapse.
View Article and Find Full Text PDFModel of superior semicircular canal dehiscence: asymmetrical vestibular dysfunction induces reversible balance impairment.
Front Neurol
October 2024
Department of Head and Neck Surgery & Communication Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States.
Background: Superior semicircular canal dehiscence (SSCD) is a vestibular-cochlear disorder in humans in which a pathological third mobile window of the otic capsule creates changes to the flow of sound pressure energy through the perilymph/endolymph. The primary symptoms include sound-induced dizziness/vertigo, inner ear conductive hearing loss, autophony, headaches, and visual problems. We have developed an animal model of this human condition in the Mongolian Gerbil that uses surgically created SSCD to induce the condition.
View Article and Find Full Text PDF[Selection of inner ear fenestration strategy and surgical effect of patients with oval window atresia accompanied by facial nerve aberration].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
September 2024
Otolaryngology Head and Neck Surgery Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Clinical Center for Hearing Loss, Capital Medical University, Beijing 100050, China.
To summarize the clinical features and postoperative efficacy of patients with oval window atresia accompanied by facial nerve aberration. The clinical data of patients with congenital middle ear malformation with facial nerve aberration admitted to our hospital from January 2015 to March 2023 were retrospectively analyzed. There were 97 cases (133 ears) in total.
View Article and Find Full Text PDFHistopathological Patterns of Otosclerosis Progression: Exploring Otic Capsule and Round Window Involvement.
Laryngoscope
January 2025
Department of Otolaryngology Head & Neck Surgery, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Article Synopsis
- * Researchers examined temporal bones from donors with otosclerosis to assess RW obliteration and its relation to other otosclerosis patterns.
- * Findings indicate a significant rate of RW involvement, with continuous lesions from the oval window leading to complete RW obliteration, potentially improving future prognostic evaluations for otosclerosis patients.
Diving technique of cochlear implant electrode insertion for hearing preservation: how I do it.
Eur Arch Otorhinolaryngol
October 2024
Department of Otorhinolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Background: Preservation of intracochlear structures and residual hearing has become a major concern in modern cochlear implant. Consequently, many efforts have been made to minimize intraoperative trauma, especially while cochlear fenestration and electrode insertion.
Methods: Building on the core concept of "soft surgery", a modified approach, described as diving technique for cochlear implant electrode array insertion is proposed.
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