The effort to revise the Declaration of Helsinki and the CIOMS Guidelines has sparked a sometimes vitriolic debate centering on the use of placebo controls.
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Collateral damage: the overlooked reproductive health crisis in conflict zones.
Reprod Health
December 2024
The George Institute for Global Health, Imperial College London, London, UK.
Conflict-affected regions face severe reproductive health challenges that disproportionately impact adolescent girls and young women (AGYW) and children, who are especially vulnerable due to the breakdown of healthcare systems and limited access to essential services. AGYW are at heightened risk due to restricted access to family planning, prenatal care, and emergency obstetric services, while children face malnutrition, disease outbreaks, and developmental delays. These challenges have profound long-term consequences for both their physical and psychological well-being.
View Article and Find Full Text PDFDeveloping a fully applicable machine learning (ML) based sex classification model using linear cranial dimensions.
Sci Rep
December 2024
University Department of Forensic Sciences, University of Split, Split, Croatia.
Recent advances in artificial intelligence (AI) and machine learning (ML) applications have elevated accomplishments in various scientific fields, primarily those that benefit the economy and society. Contemporary threats, such as armed conflicts, natural and man-made disasters, and illegal immigration, often require fast and innovative but reliable identification aids, in which forensic anthropology has a significant role. However, forensic anthropology has not yet exploited new scientific advances but instead relies on traditionally used methods.
View Article and Find Full Text PDFSurrogate Wars: The "Best Interest Values" Hierarchy & End-of-Life Conflicts with Surrogate Decision-Makers.
HEC Forum
December 2024
University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA, 19102, USA.
Conflicts involving end-of-life care between healthcare providers (HCPs) and surrogate decision-makers (SDMs) have received sustained attention for more than a quarter of a century, with early studies demonstrating a frequency of HCP-SDM conflict in ICUs ranging from 32-78% of all admissions (Abbott et al. 2001; Breen et al. 2001; Studdert et al.
View Article and Find Full Text PDFExploring the inherent resilience of health districts in a context of chronic armed conflict: a case study in Eastern Democratic Republic of the Congo.
Health Res Policy Syst
December 2024
Ecole de Santé Publique, Université Libre de Bruxelles, Brussels, Belgium.
Background: In South Kivu (Eastern Democratic Republic of the Congo [DRC]), health districts (HDs) affected by chronic armed conflicts are devising coping mechanisms to continue offering healthcare services to the population. Nonetheless, this alone does not suffice to make them fully resilient to such conflicts. This study aims to explore the characteristics of these HDs' resilience.
View Article and Find Full Text PDFThe Implementation and Outcomes of Personalized Antihypertensive Therapy Based on Pharmacogenetic Testing: A Retrospective Study Examining Blood Pressure Control and Medication Tolerability.
Cureus
November 2024
Medicine Department, Khyber Medical University, Peshawar, PAK.
Background: Hypertension management typically relies on standardized treatment regimens, which may not account for individual genetic variations that affect drug metabolism and response.
Objective: The objective of this study was to evaluate the effectiveness of personalized antihypertensive therapy, guided by pharmacogenetic testing, in terms of blood pressure (BP) control and medication tolerability.
Materials And Methods: A retrospective cohort study was conducted at Jinnah Postgraduate Medical Centre, Karachi, from January 2023 to December 2023.
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