The aim of this experiment was to test the influence of target context on adaptation to scale perturbations introduced by a video display. Participants performed pointing movements without direct vision of their moving hand, although they could see their movements on a video display. Their perceived movements could be reduced, enlarged. or displayed at their actual size. Three target contexts were compared: dark surround, illuminated frame, and familiar object. Movements were executed with or without vision of hand displacement. Results showed that target context enhanced an allocentric coding of the movement, which improved movement execution. However, the effect of target context changed whether or not the displacement of the hand was available. Overall, the results suggest that target context allowed the extraction of dynamic information about movements, which is used to program and control movements. This suggests that target context could be used efficiently to improve spatial accuracy and speed in teleoperation learning. Potential applications include the reduction of difficulties encountered during teleoperation learning through the introduction of visual context.
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http://dx.doi.org/10.1518/001872001775992516 | DOI Listing |
JMIR Pediatr Parent
January 2025
Department of Health and Physical Education, Mount Royal University, Calgary, AB, Canada.
Background: Early childhood is a critical period for shaping lifelong health behaviors, making early childhood education and care (ECEC) environments ideal for implementing nutrition and physical activity interventions. eHealth tools are increasingly utilized in ECEC settings due to their accessibility, scalability, and cost-effectiveness, demonstrating promise in enhancing educators' practices. Despite the potential effectiveness of these eHealth approaches, a comprehensive collection of available evidence on eHealth tools designed to assess or support best practices for nutrition or physical activity in ECECs is currently lacking.
View Article and Find Full Text PDFJ Speech Lang Hear Res
January 2025
Department of Speech, Language, and Hearing Sciences, The University of Arizona, Tucson.
Purpose: The purpose of this study was to determine if the Vocabulary Acquisition and Usage for Late Talkers (VAULT) intervention could be efficaciously applied to a new treatment target: words a child neither understood nor said. We also assessed whether the type of context variability used to encourage semantic learning (i.e.
View Article and Find Full Text PDFSci Transl Med
January 2025
Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Chimeric antigen receptor (CAR)-T cell therapies have revolutionized the landscape of cancer treatment, in particular in the context of hematologic malignancies. However, for solid tumors that lack tumor-specific antigens, CAR-T cells can infiltrate and attack nonmalignant tissues expressing the CAR target antigen, leading to on-target, off-tumor toxicity. Severe on-target, off-tumor toxicities have been observed in clinical trials of CAR-T therapy for solid tumors, highlighting the need to address this issue.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Occupational Science & Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Background: Health and social care systems must confront the challenge of supporting a growing elderly population and their caregivers. Family caregivers who are healthcare professionals are part of this context, but their caregiving experiences remain unclear.
Objective: This scoping review explored the experiences of healthcare professionals who are also family caregivers for older adults.
PLoS Genet
January 2025
Waksman Institute, Rutgers University, Piscataway, New Jersey, United States of America.
Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances and altered synaptic function. Cul3 engages dozens of adaptor proteins to recruit hundreds of substrates for ubiquitination, but the adaptors that impact sleep and synapses remain ill-defined. Here we implicate Insomniac (Inc), a conserved protein required for normal sleep and synaptic homeostasis in Drosophila, as a Cul3 adaptor.
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