AI Article Synopsis
Article Abstract
We propose a rapid method for the measurement of octanol/water partition coefficients (log P(oct)) via fast gradient reversed phase retention and the calculation of the hydrogen bond acidity of the compounds. The cycle time of the generic gradient HPLC method is 5 minutes. The general solvation equation obtained for the log Poct values and the fast gradient Chromatographic Hydrophobicity Indices with acetonitrile (CHI(ACN)) and methanol
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/0929867013372643 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Brain endothelial permeability, transport, and flow assessed over 10 orders of magnitude using the in situ brain perfusion technique.
Fluids Barriers CNS
December 2024
National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Background: Cerebral blood flow normally places a limit on the magnitude of brain vascular permeability (P) that can be measured in vivo. At normal cerebral blood flow, this limit falls at the lower end of lipophilicity for most FDA-approved CNS drugs. In this study, we report on two methods that can be used to overcome this limitation and measure brain vascular permeability values that are up to ~1000 times higher using the in situ brain perfusion technique.
View Article and Find Full Text PDFAntimicrobial Activity of Copolymer Structures from Bio-Based Monomers.
Biomacromolecules
December 2024
CEMMPRE, ARISE, Department of Chemical Engineering, University of Coimbra, Coimbra 3030-790, Portugal.
The urgent need for new antimicrobial compounds has led scientists to explore antimicrobial peptides (AMPs) and antimicrobial polymers as solutions for multidrug resistance. In this study, we synthesized copolymers with cationic and hydrophobic moieties by free-radical polymerization (FRP) using a chain transfer agent to control molecular weights. The potential of natural products as part of the hydrophobic moiety was evaluated, along with variations in their monomer content (13-25%) and the molecular weight (MW) of the copolymer (5000-20,000 g·mol).
View Article and Find Full Text PDFTowards a Point-of-Care Test of CD4 T Lymphocyte Concentrations for Immune Status Monitoring with Magnetic Flow Cytometry.
Micromachines (Basel)
April 2024
Heinz-Nixdorf-Chair of Biomedical Electronics, School of Computation, Information and Technology & Munich Institute of Biomedical Engineering, Technical University of Munich, TranslaTUM, Einsteinstraße 25, 81675 Munich, Germany.
For the treatment of human immunodeficiency virus (HIV)-infected patients, the regular assessment of the immune status is indispensable. The quantification of CD4 T lymphocytes in blood by gold standard optical flow cytometry is not point-of-care testing (POCT) compatible. This incompatibility is due to unavoidable pre-analytics, expensive and bulky optics with limited portability, and complex workflow integration.
View Article and Find Full Text PDFA laser-induced graphene-based electrochemical immunosensor for nucleic acid methylation detection.
Analyst
December 2023
School of Pharmaceutical Sciences, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Wuhan University, Wuhan, 430071, China.
The detection of methylation in DNA and RNA is essential for the diagnosis and treatment of a wide range of diseases. A one-step fabricated laser-induced graphene (LIG) electrode has received increasing attention due to its good electrical conductivity, large specific surface area, ease of miniaturization, low cost and flexibility. Herein, a potential biosensor for N6-methyladenosine (m6A-RNA) and 5-methylcystosine-single strand DNA (5mC-ssDNA) detection was designed.
View Article and Find Full Text PDF[Detection and analysis of moving reaction boundary-based electrophoresis distance using smartphone images].
Se Pu
September 2023
School of Electronic Information & Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Electrophoresis titration (ET) based on the moving reaction boundary (MRB) theory can detect the analyte contents in different samples by converting content signals into distance signals. However, this technique is only suitable for on-site qualitative testing, and accurate quantification relies on complex optical equipment and computers. Hence, applying this method to real-time point-of-care testing (POCT) is challenging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!