Purpose: To determine if model eyes can simulate the visual performance of normal human eyes under conditions of varying low myopic blur, pupil size, and contrast.
Methods: High and low contrast Bailey-Lovie logMAR visual acuity (VA) of three normal eyes of three subjects were measured for four artificial pupil sizes and ten levels of myopic defocus. Simulated visual acuities were then determined for three model eyes--the Indiana Eye with no spherical aberration, the Indiana Eye with average spherical aberration, and the Kooijman Eye--by generating optically aberrated VA charts for each testing condition using Visual Optics Lab software by Sarver and Associates, Inc, and having the subjects read high resolution printouts of these charts using a 3-mm pupil and optimal spectacle correction. The correlation between real VA and simulated VA was then plotted and a regression line calculated.
Results: Slopes for the Indiana Eye, Indiana Eye with spherical aberration, and Kooijman Eye were 0.98, 0.98, and 1.01 for high contrast, and 0.92, 0.67, and 0.75 for low contrast, respectively. The r2 values were 0.73, 0.74, and 0.77, for high contrast, and 0.69, 0.40, and 0.50 for low contrast, respectively. Under low contrast conditions the Indiana Eye VA was significantly closer to the real VA than that of the other two models (P<.0003).
Conclusion: Visual performance can be simulated by eye models. The simple single surface Indiana Eye with no spherical aberration best modeled both high and low contrast visual acuity.
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http://dx.doi.org/10.3928/1081-597X-20010701-02 | DOI Listing |
Am J Ophthalmol
January 2025
Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan; Center for Eye Policy and Innovation, University of Michigan, Ann Arbor, Michigan; Department of Health Management and Policy, University of Michigan School of Public Health, Ann Arbor, Michigan. Electronic address:
Purpose: A previously developed machine-learning approach with Kalman-filtering technology accurately predicted disease trajectory for patients with various glaucoma types and severities using clinical trials data. This study assesses performance of the KF approach with real-world data.
Design: Retrospective cohort study.
PLoS Biol
January 2025
Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
Pathogenic mutations that cause rhodopsin misfolding lead to a spectrum of currently untreatable blinding diseases collectively termed retinitis pigmentosa. Small molecules to correct rhodopsin misfolding are therefore urgently needed. In this study, we utilized virtual screening to search for drug-like molecules that bind to the orthosteric site of rod opsin and improve its folding and trafficking.
View Article and Find Full Text PDFBMJ Open
December 2024
Human Development and Family Science, Purdue University, West Lafayette, Indiana, USA.
Introduction: Despite evidence of variation in how concerns about falling influence physical activity, many of the currently available knowledge syntheses merely assume that this relation is uniform across populations and contexts. Therefore, we propose a scoping review protocol to guide a summary of the bodywork that has examined the association between concerns about falling and physical activity in adult populations, with an eye on the availability of empirical evidence of moderation.
Methods And Analyses: Studies reporting on both the concepts of concerns about falling and physical activity among samples with a mean age≥18 years will be included.
Am J Hum Genet
January 2025
Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Institute of Human Genetics, University of Regensburg, 93053 Regensburg, Germany; Institute of Clinical Human Genetics, University Hospital Regensburg, 93053 Regensburg, Germany. Electronic address:
BCL11B is a Cys2-His2 zinc-finger (C2H2-ZnF) domain-containing, DNA-binding, transcription factor with established roles in the development of various organs and tissues, primarily the immune and nervous systems. BCL11B germline variants have been associated with a variety of developmental syndromes. However, genotype-phenotype correlations along with pathophysiologic mechanisms of selected variants mostly remain elusive.
View Article and Find Full Text PDFOphthalmol Retina
January 2025
Department of Ophthalmology, Glick Eye Institute, Indiana University School of Medicine, Indianapolis, Indiana.
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