The casein kinase I (CKI) family of protein kinases is a group of highly related, ubiquitously expressed serine/threonine kinases found in all eukaryotic organisms from protozoa to man. Recent advances in diverse fields, including developmental biology and chronobiology, have elucidated roles for CKI in regulating critical processes such as Wnt signaling, circadian rhythm, nuclear import, and Alzheimer's disease progression.
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CK2-dependent SK channel dysfunction as contributor to neuronal hyperexcitability in Alzheimer's disease.
Trends Neurosci
January 2025
Department of Anesthesiology of the Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Zhejiang University, Hangzhou, Zhejiang Province 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310058, China. Electronic address:
Neuronal hyperexcitability in the cortex and hippocampus represents an early event in Alzheimer's disease (AD). In a recent study, Blankenship and colleagues reported that in a mouse of AD, ventral tegmental area (VTA) dopamine neurons are also hyperexcitable, and this hyperexcitability is due to casein kinase 2 (CK2)-dependent SK channel dysfunction, adding new insights into the underlying mechanisms of aberrant neuronal properties in AD.
View Article and Find Full Text PDFDevelopment and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε.
J Med Chem
December 2024
Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Members of the casein kinase 1 (CK1) family have emerged as key regulators of cellular signaling and as potential drug targets. Functional annotation of the 7 human isoforms would benefit from isoform-selective inhibitors, allowing studies on the role of these enzymes in normal physiology and disease pathogenesis. However, due to significant sequence homology within the catalytic domain, isoform selectivity is difficult to achieve with conventional small molecules.
View Article and Find Full Text PDFOptimization of Protoplast Preparation Conditions in and Transcriptomic Analysis Throughout the Process.
J Fungi (Basel)
December 2024
College of Agriculture, Yanbian University, Yanji 133002, China.
Protoplasts are essential tools for genetic manipulation and functional genomics research in fungi. This study systematically optimized protoplast preparation conditions and examined transcriptional changes throughout the preparation and regeneration processes to elucidate the molecular mechanisms underlying the formation and regeneration of protoplasts in . The results indicated an optimal protoplast yield of 5.
View Article and Find Full Text PDFCurzerenone inactivates the nuclear factor-kappa B signaling to suppress malignancy and immune evasion in cervical cancer by targeting CSNK2B.
Hum Cell
December 2024
Department of Gynecology, Jiangyin Hospital Affiliated to Nantong University, Wuxi, 214400, Jiangsu, People's Republic of China.
Curzerenone is a major component of the traditional herbal medicine Curcumae Rhizoma with potential cancer-suppressing effects. This study aims to investigate the treatment effect of Curzerenone on cervical cancer cells and the underpinning mechanism. HeLa and SiHa cells were treated with Curzerenone.
View Article and Find Full Text PDFCasein kinase 1 controls components of a TORC2 signaling network in budding yeast.
J Cell Sci
December 2024
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Article Synopsis
- TOR kinases are crucial for nutrient signaling and cell growth, organized into TORC1 and TORC2 complexes.
- In budding yeast, TORC2 is particularly important for regulating growth rate and cell size, but how it functions is not fully understood.
- Researchers discovered that the kinases Yck1 and Yck2 significantly impact the phosphorylation and localization of Mss4, a key player in TORC2 signaling, but their inhibition has minor effects on well-characterized pathways, indicating a potential role in less defined TORC2 functions.
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