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Introduction: The recommended target temperature in the treatment of comatous patients after cardiac arrest has recently changed. We analyzed the impact on the neurological outcome of a change in the target temperature from July 2021.

Material And Methods: This was a retrospective analysis comparing the discharge status of 78 patients with a target temperature of 33 °C (group 1) with that of 24 patients with a target temperature of 36.

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A rare case of aCML associated with CNS involvement and with aggressive clinical course.

Leuk Res Rep

January 2023

Università Politecnica delle Marche, Azienda Ospedaliera Universitaria delle Marche, Hematology Clinic, Italy.

Article Synopsis
  • The case discusses a 78-year-old woman with severe leukocytosis and anemia who initially appeared asymptomatic and was hospitalized for a routine check-up.
  • After an abdominal ultrasound showed mild splenomegaly, further examinations revealed a significant decline in her cognitive function and multiple brain lesions a week later.
  • An autopsy confirmed extreme infiltration of leukemia in various organs, indicating a complex condition potentially classified as an overlap syndrome between atypical chronic myeloid leukemia (aCML) and myelodysplastic/myeloproliferative neoplasm (MDS/MPN), making diagnosis challenging.
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Two patients with post-coma reactivation deficiency who showed a "dramatic" response to rotigotine therapy are described. They had suffered from prolonged coma due to lesions in the mesencephalic ventral tegmental area. The authors believe that rotigotine effect in these cases could be due to restoration of dopaminergic transmission in medial frontal areas previously "de-afferented" from the lesions.

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Background: Intracranial vascular infections of fungal etiology are extremely rare. Most cases occur in immunocompromised patients with invasive fungal disease, most commonly originating in the paranasal sinuses or the lungs. Granulomatous invasive rhinosinusitis, which is extremely rare in North America, has been reported to affect immunocompetent patients in most cases, and its causative strain has potential to invade the intracranial arteries.

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Background And Aim: Post-traumatic hydrocephalus is a common complication that arises after head injury. However, risk factors associated with the outcome of post-traumatic hydrocephalus have seldom been addressed. Therefore, we performed this clinical study to analyze the risk factors affecting the outcome of post-traumatic hydrocephalus in patients with head injuries.

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