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Development of a Stability-Indicating Purity Method for Ubrogepant Through Stress Degradation Analysis, Extraction, and Characterization of Unidentified Degradation Products Using Flash Chromatography, NMR, IR, and LC-MS.
J AOAC Int
October 2024
Industrial Chemical Product Development and Analysis Centre, Department of Chemistry, GITAM Deemed to be University-Bengaluru Campus, Bengaluru, Karnataka 561203, India.
Background: Ubrogepant is a prescription medication used to prevent migraine headaches. It is currently available in tablet form.
Objective: The goal of this work is to investigate the drug degradation profile of ubrogepant, as well as to isolate and characterize undiscovered ubrogepant degradation products by utilizing LC-MS, NMR, and IR spectroscopic analytical techniques and, furthermore, to develop a high-resolution, sensitive, stability-indicating analytical approach for detecting and quantifying ubrogepant degradation products in its pharmaceutical formulation.
EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods.
J Gen Physiol
September 2023
Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, Omaha, NE, USA.
Light responses of rod photoreceptor cells in the retina are encoded by changes in synaptic glutamate release that is in turn shaped by reuptake involving EAAT5 plasma membrane glutamate transporters. Heterologously expressed EAAT5 activates too slowly upon glutamate binding to support significant uptake. We tested EAAT5 activation in mouse rods in vivo by stimulating glutamate transporter anion currents (IA(glu)) with UV flash photolysis of MNI-glutamate, varying flash intensity to vary glutamate levels.
View Article and Find Full Text PDFPhotochemistry of phosphenic chloride (ClPO): isomerization with chlorine metaphosphite (ClOPO) and reduction by carbon monoxide.
Phys Chem Chem Phys
September 2022
Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysts and Innovative Materials, Fudan University, Shanghai, 200433, China.
Phosphenic chloride (ClPO) is an elusive congener of nitryl chloride (ClNO). By high-vacuum flash pyrolysis of 2-chloro-1,3,2-dioxaphospholane in the gas phase, ClPO has been efficiently generated and subsequently isolated in cryogenic N, Ar, and CO matrices (10 K) for a first time study on its photochemistry. Upon 193 nm laser irradiation, ClPO isomerizes to the novel chlorine metaphosphite (ClOPO) by initial cleavage of the Cl-P bond (→ ˙Cl + ˙PO) with subsequent Cl-O bond formation inside the N and Ar matrix cages.
View Article and Find Full Text PDFDetection of excited triplet species from photolysis of carbonyls: Direct evidence for single oxygen formation in atmospheric environment.
Sci Total Environ
September 2022
Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Guangdong Technology Research Center for Photocatalytic Technology Integration and Equipment Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China.
Excited triplet species play an important role in the photolytic formation of O from carbonyls, but the related mechanism is still uncertain, due to lack of direct evidence. In this study, steady-state and transient photolysis of eleven carbonyls to produce O was investigated. Dicarbonyl displayed greater O production ability than monocarbonyl, while dicarbonyl containing both ketone and carboxyl groups connected by CC bond (i.
View Article and Find Full Text PDFNucleophilicities and Nucleofugalities of Thio- and Selenoethers.
Chemistry
August 2021
Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, München, Germany.
Rate constants for the reactions of dialkyl chalcogenides with laser flash photolytically generated benzhydrylium ions have been measured photometrically to integrate them into the comprehensive benzhydrylium-based nucleophilicity scale. Combining these rate constants with the previously reported equilibrium constants for the same reactions provided the corresponding Marcus intrinsic barriers and made it possible to quantify the leaving group abilities (nucleofugalities) of dialkyl sulfides and dimethyl selenide. Due to the low intrinsic barriers, dialkyl chalcogenides are fairly strong nucleophiles (comparable to pyridine and N-methylimidazole) as well as good nucleofuges; this makes them useful group-transfer reagents.
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