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Phase I and Randomized Phase II Study of Ruxolitinib With Frontline Neoadjuvant Therapy in Advanced Ovarian Cancer: An NRG Oncology Group Study.
J Clin Oncol
July 2024
Department of Medical Oncology, Kaiser-Permanente Northern California, San Francisco, CA.
Purpose: The interleukin-6/Janus kinase (JAK)/signal transducers and activators of transcription 3 axis is a reported driver of chemotherapy resistance. We hypothesized that adding the JAK1/2 inhibitor ruxolitinib to standard chemotherapy would be tolerable and improve progression-free survival (PFS) in patients with ovarian cancer in the upfront setting.
Materials And Methods: Patients with ovarian/fallopian tube/primary peritoneal carcinoma recommended for neoadjuvant chemotherapy were eligible.
Association Between Capitated Payments and Preventive Care Among U.S. Adults.
AJPM Focus
September 2023
Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
Article Synopsis
- The study explores the impact of different payment structures for primary care (capitation vs. fee-for-service) on the delivery of preventive health services from 2012 to 2018.
- It utilizes data from a large survey to analyze how these reimbursement methods influence the likelihood of patients receiving specific screenings and health counseling.
- Findings suggest that capitation may lead to higher rates of certain screenings, like breast and osteoporosis, but does not significantly affect other preventive services or counseling options.
Quantitative 3-D CT Demonstrates Distal Row Pronation and Translation and Radiolunate Arthritis in the SNAC Wrist.
J Bone Joint Surg Am
September 2023
Hand and Upper Extremity Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Background: In scaphoid nonunion advanced collapse (SNAC) wrist arthritis, we analyzed the 3-dimensional (3-D) deformity patterns of carpal alignment secondary to scaphoid nonunion and quantified subchondral arthritis by investigating alterations in bone density.
Methods: We constructed 3-D models of the carpal bones and radius from 51 patients with scaphoid nonunion (nonunion group) and 50 healthy controls (control group). We quantified the differences in 3-D geometric position of the distal carpal row relative to the distal radius in SNAC wrists versus controls.
Variation in Commercial Insurance Type Impacts Access to Cervical Spine Surgery.
Spine (Phila Pa 1976)
July 2023
Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, MD.
Introduction: Prior literature has demonstrated that disparities exist in health care access and outcomes by insurance status, and patients with commercial plans fare better than those with Medicaid. However, variation may exist within commercial plans, which may impact care access. The purpose of our study was to determine the association between commercial health insurance plan type and access/time to surgery among patients with degenerative cervical conditions.
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