Objective: To develop an accurate method for performing histopathologic analysis for a full cross-section of cortical bone within 2 to 3 hours.
Methods: Microwave technology was used to augment and to more rapidly perform fixation and decalcification of cortical bone.
Results: Using the methods described, slides suitable for histopathologic analyses regarding the presence or absence of malignant tumor were prepared in 2 to 3 hours and, in 10 patients studied, had a 100% correlation with slides prepared in 7 days using the standard decalcification technique.
Conclusion: Microwave technology allows accurate assessment of a full cross-section of cortical bone regarding the presence or absence of malignant tumor within the time limits required for resection of a malignant head and neck tumor and reconstruction of the surgical defect.
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