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In vivo assessment of pediatric kidney function using multi-parametric and multi-nuclear functional magnetic resonance imaging: challenges, perspectives, and clinical applications.
Pediatr Nephrol
November 2024
Service de Néphrologie Et d'exploration Fonctionnelle Rénale, Hôpital Édouard-Herriot, Hospices Civils de Lyon, Lyon, France.
Article Synopsis
- Conventional kidney function tests like glomerular filtration rate offer limited insight, while advanced multi-parametric and multi-nuclear MRI techniques provide a more comprehensive understanding of kidney physiology, including assessing perfusion and tissue characteristics without invasive methods.
- Multi-parametric MRI can evaluate critical aspects of kidney health, such as fibrosis and oxygenation, while multi-nuclear MRI techniques like sodium and phosphorus MRI enable insights into sodium storage and oxidative metabolism, relevant for conditions like chronic kidney disease.
- These non-invasive MRI techniques are particularly advantageous for pediatric patients, allowing for longitudinal assessments and improved understanding of kidney function with minimal risk and short acquisition times.
Renal tubular dysfunction in greenhouse farmers exposed to pesticides unveiled by a panel of molecular biomarkers of kidney injury.
Environ Res
December 2023
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Spain; Instituto de Investigación Biosanitaria, Granada (ibs.GRANADA), Spain; Department of Legal Medicine and Toxicology, University of Granada School of Medicine, Granada, Spain. Electronic address:
Article Synopsis
- Chronic exposure to pesticides is linked to kidney damage in populations, necessitating more sensitive biomarkers for assessment.
- Traditional renal function markers like GFR and serum creatinine are insufficient as they only indicate extensive renal damage.
- The study found elevated levels of urinary biomarkers OPN and TFF3 in greenhouse workers during high pesticide exposure, indicating early signs of kidney tubular damage rather than glomerular issues.
Left ventricular longitudinal strain in patients with type 2 diabetes mellitus is independently associated with glycated hemoglobin level.
Clin Cardiol
December 2023
Department of Medical Imaging, The Third Affiliated Hospital of Soochow University, Chang Zhou, China.
Objective: Left ventricular and left atrial strain are sensitive and reliable markers for evaluating cardiac function in patients with type 2 diabetes mellitus (T2DM), with interactions between the two parameters. The present study aimed to analyze the correlation between global longitudinal strain (GLS) of the left ventricle and glycated hemoglobin (HbA1c) levels in patients with T2DM.
Methods: A total of 292 patients clinically diagnosed with T2DM were selected and divided into three groups according to HbA1c level.
Microvascular and Endothelial Dysfunction in Prediabetes.
Life (Basel)
February 2023
Third Department of Internal Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.
Prediabetes is a significant metabolic status since there is high potential for future progression of diabetes mellitus (DM). People with prediabetes are at increased risk of cardiovascular disease (CVD) and mortality. Endothelial and microvascular dysfunction is considered a key step towards the development and progression of CVD.
View Article and Find Full Text PDFObstructive Sleep Apnea and Right Ventricular Remodeling: Do We Have All the Answers?
J Clin Med
March 2023
Department of Medicine and Surgery, University of Milano-Bicocca, 20125 Milano, Italy.
Obstructive sleep apnea (OSA) syndrome is a very important sleep-related breathing disorder related to increased cardiovascular and overall morbidity and mortality. It is associated with multisystemic target organ damage due to micro- and macrovascular changes, resulting in carotid and coronary atherosclerosis, increased arterial stiffness, retinal damage, microalbuminuria, and cardiac remodeling. The latter consists of left ventricular (LV) hypertrophy, as well as diastolic and systolic dysfunction.
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