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During 3 years, the usefulness of proxibarbal (Ipronal "Polfa") for gastro-duodenal ulcer recurrences prophylaxis has been studie in 62 patients in 7 clinics. A history of the gastro-duodenal ulcers, physical examinations, X-ray, and endoscopy consisted diagnostic and evaluation criteria. The drug was tested with double blind trial; 33 patients received proxibarbal in tablets of 50 mg and 29 persons received placebo tablets.
View Article and Find Full Text PDF[Treatment of psycho-neuro-autonomic disorders of menopause: contribution of veralipride compared with a barbiturate sedative (proxibarbal)].
Rev Fr Gynecol Obstet
December 1987
Service de Gynécologie-Obstétrique, Centre Hospitalier Universitaire, Reims.
Pharmacokinetics of 14C-2-allophanyl-2-allyl -gamma-valero-lactone: a prodrug of proxibarbal in rats.
Eur J Drug Metab Pharmacokinet
February 1982
The pharmacokinetics and metabolism of 2-allophanyl-2-allyl-gamma-valerolactone (AAV) was studied in rats. AAV was partially transformed to proxibarbal and urea, and its urinary elimination was very rapid. AAV becomes widely distributed in tissues and peak concentrations are reached rapidly.
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