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In Vivo Detection of Lymph Nodes Metastasis of ESCC Using CXCR4-Targeted Tracer [Cu]Cu-NOTA-CP01.
Mol Imaging Biol
December 2024
Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, 519000, China.
Article Synopsis
- This study explores a new method for visualizing metastatic lymph nodes (MLN) in esophageal squamous cell carcinoma (ESCC) using a CXCR4-targeted tracer called [Cu]Cu-NOTA-CP01, aiming to provide a non-invasive alternative to traditional biopsies.
- Researchers established an intralymphatic tumor metastasis model and utilized bioluminescence imaging and PET/CT scans to assess the tracer's effectiveness and specificity for detecting MLN.
- Results showed that the tracer successfully highlighted metastatic lymph nodes, indicating high CXCR4 expression and suggesting that this method could be a promising tool for monitoring cancer progression in patients.
Breaking the mold: nontraditional approaches to allergen immunotherapy for environmental allergens.
Immunotherapy
December 2024
Allergy Research Unit, Kingston Health Sciences Center - KGH Site, Kingston, ON, Canada.
Article Synopsis
- * Nontraditional immunotherapy options, like sublingual and intralymphatic methods, are emerging as promising alternatives that could offer shorter treatment times and improved safety and effectiveness compared to traditional methods.
- * More research, including large-scale and long-term studies, is necessary to standardize treatment protocols and accurately compare the outcomes of these new therapies before they become widely adopted in clinical practice.
Evaluation of inguinal and axillary lymph node size distribution for Intralymphatic injection.
Allergy
September 2024
Division of Respiratory Disease and Allergy, Department of Internal Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Republic of Korea.
Fluctuation of Disease Severity and Quality of Life Applying Intralymphatic Immunotherapy for Patients with Seasonal Allergic Rhinitis.
Iran J Allergy Asthma Immunol
April 2024
Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Allergen-specific immunotherapy is the only disease-modifying treatment for IgE-mediated allergic disorders. Intra lymphatic immunotherapy (ILIT) is an efficacious and time-saving alternative to subcutaneous immunotherapy (SCIT). This study aimed to evaluate the effects and safety of ILIT in patients with moderate to severe allergic rhinitis.
View Article and Find Full Text PDFA meta-analysis investigating the efficacy and safety of allergen-specific immunotherapy in the management of respiratory allergies.
J Asthma
October 2024
Pneumology Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Background: This meta-analysis aimed to evaluate the effectiveness and adverse effects of specific immunotherapy (SIT) in the management of respiratory allergens, including allergic asthma, rhinitis, and related disorders, based on a review of current literature up to November 8, 2022.
Methods: We conducted a search of databases, including PubMed, Embase, Cochrane, and Web of Science, to identify relevant randomized controlled trials (RCTs) assessing respiratory allergy-specific immunotherapy. We employed the Consolidated Standards of Reporting Trials (CONSORT) Statement to select RCTs that adhered to rigorous reporting standards.
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