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Dokl Biol Sci
February 2024
Moscow State University, Moscow, Russia.
Free endings of peripheral neurosecretory neurons (NNs) were found in the tegument of plerocercoids of five species of parasitic cestodes of fish in an ultrastructural study. The free terminals secreted vesicles on the tegument surface and into the host body. Secretion was experimentally shown to increase in response to the host fish blood serum.
View Article and Find Full Text PDFZoology (Jena)
October 2023
Lomonosov Moscow State University, Faculty of Biology, Department of Invertebrate Zoology, Moscow 119234, Russia.
The phenomenon of exocrine secretion via nervous cells into the host tissue has been discovered in cestodes. In five cestode species of different orders specialized "cup-shaped" free nerve endings located in the tegument have been found. Their ultrastructure is characterized by the presence of a septate junction, a thin support ring and neurosecretory vesicles 90-110 nm in diameter, which are secreted onto the surface of the tegument through a thin pore.
View Article and Find Full Text PDFCrit Rev Immunol
April 2019
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York.
The discovery of the ability of the nervous system to communicate through "public" circuits with other systems of the body is attributed to Ernst and Berta Scharrer, who described the neurosecretory process in 1928. Indeed, the immune system has been identified as another important neuroendocrine target tissue. Opioid peptides are involved in this communication (i.
View Article and Find Full Text PDFJ Cell Sci
July 2010
Institute of Parasitology and Biomedicine López-Neyra, Consejo Superior de Investigaciones Científicas, Avda del Conocimiento s/n, 18100 Granada, Spain.
Neurosecretion involves fusion of vesicles with the plasma membrane. Such membrane fusion is mediated by the SNARE complex, which is composed of the vesicle-associated protein synaptobrevin (VAMP2), and the plasma membrane proteins syntaxin-1A and SNAP-25. Although clearly important at the point of membrane fusion, the precise structural and functional requirements for the transmembrane domains (TMDs) of SNAREs in bringing about neurosecretion remain largely unknown.
View Article and Find Full Text PDFMol Biol Cell
August 2008
Institute of Parasitology and Biomedicine López-Neyra, Consejo Superior de Investigaciones Cientificas, 18100 Granada, Spain.
The interactions underlying the cooperativity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes during neurotransmission are not known. Here, we provide a molecular characterization of a dimer formed between the cytoplasmic portions of neuronal SNARE complexes. Dimerization generates a two-winged structure in which the C termini of cytosolic SNARE complexes are in apposition, and it involves residues from the vesicle-associated SNARE synaptobrevin 2 that lie close to the cytosol-membrane interface within the full-length protein.
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