Sparganum proliferum is a larval cestode for which the adult stage is unknown. It is characterized by the continuous branching and budding when parasitized to humans, and causes fatal human sparganosis. However, the biological features of S. proliferum, including its taxonomic status, still remain obscure. Our previous investigation suggested that S. proliferum might be phylogenetically distinct from Spirometra erinaceieuropaei, by the analysis on mitochondrial NADH dehydrogenase subunit 3 (ND3) gene. However, mitochondrial DNA sequence in Platyhelminth is known to have heteroplasmy within a species. Therefore, in the present study, we have investigated the complete nucleotide sequences of mitochondrial cytochrome c oxidase subunit I (COI) gene and the partial nucleotide sequences of nuclear coded succinate dehydrogenase iron-sulfur protein subunit gene (sdhB). The results clearly demonstrated that S. proliferum is a distinct species from S. erinaceieuropaei, and that S. proliferum belongs to the order Pseudophyllidea.
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Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation.
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Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
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- The parasite Sparganum proliferum is rare but always fatal in humans, invading tissues and organs without clear understanding of its biology or life cycle.
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Global genetic diversity of Spirometra tapeworms.
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Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, People's Republic of China.
Spirometra larvae are etiological agents of human sparganosis. However, the systematics of spirometrid cestodes has long been controversial. In order to determine the current knowledge on the evolution and genetic structure of Spirometra, an exhaustive population diversity analysis of spirometrid cestodes using the mitochondrial gene: cytochrome c oxidase subunit 1 (cox1) was performed.
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IMPAM-UBA-CONICET, Instituto de Investigaciones en Microbiología y Parasitología Médica, Facultad de Medicina - Universidad de Buenos Aires, Paraguay 2155, piso 13 (1121), Buenos Aires, Argentina.
After decades of being neglected, broad tapeworms now attract growing attention thanks to the increasing number of reports from humans but also thanks to many advancements achieved by application of molecular methods in diagnosis and epidemiological studies. Regarding sparganosis, unfortunately general uniformity of most species, their high intraspecific variability and lack of agreement among researchers has led to confusion about the classification of species. For the first time we determined adult, eggs and plerocercoid life cycle stages and the molecular phylogeny of obtained from endangered wild felids ( and ) in one of the largest continuous remnants of worldwide biodiversity, the Atlantic Forest from South America.
View Article and Find Full Text PDFHuman proliferative sparganosis update.
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Department of Infectious Diseases, Division of Parasitology, Faculty of Medicine, University of Miyazaki, Japan. Electronic address:
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- Proliferative sparganosis is a rare and complex parasitic disease caused by the parasite Sparganum proliferum, distinct from Spirometra tapeworms, and has been documented in human cases for over a century.
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Broad tapeworms (Diphyllobothriidae), parasites of wildlife and humans: Recent progress and future challenges.
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Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branišovská 31, 370 05, České Budějovice, Czech Republic.
Tapeworms of the family Diphyllobothriidae, commonly known as broad tapeworms, are predominantly large-bodied parasites of wildlife capable of infecting humans as their natural or accidental host. Diphyllobothriosis caused by adults of the genera , and is usually not a life-threatening disease. Sparganosis, in contrast, is caused by larvae (plerocercoids) of species of and can have serious health consequences, exceptionally leading to host's death in the case of generalised sparganosis caused by ''.
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