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Comparative Effectiveness of Individual Sodium-Glucose Cotransporter 2 Inhibitors.
JAMA Intern Med
January 2025
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Importance: Evidence on cardiovascular benefits and safety of sodium-glucose cotransporter 2 (SGLT-2) inhibitors is mainly from placebo-controlled trials. Therefore, the comparative effectiveness and safety of individual SGLT-2 inhibitors remain unknown.
Objective: To compare the use of canagliflozin or dapagliflozin with empagliflozin for a composite outcome (myocardial infarction [MI] or stroke), heart failure hospitalization, MI, stroke, all-cause death, and safety outcomes, including diabetic ketoacidosis (DKA), lower-limb amputation, bone fracture, severe urinary tract infection (UTI), and genital infection and whether effects differed by dosage or cardiovascular disease (CVD) history.
Plain Language Summary of Publication: What is the effect of the medicine vibegron in the treatment of overactive bladder in patients with and without bladder leakage?
Ther Adv Urol
January 2025
Sumitomo Pharma America, Inc., Marlborough, MA, USA.
What is this summary about? People with overactive bladder need to use the bathroom many times a day to urinate (pee). This need may often be sudden and may cause some people with overactive bladder to have accidental bladder leakage. The EMPOWUR trial looked at how well a medicine called worked to help people with overactive bladder.
View Article and Find Full Text PDFThe pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology.
Front Pharmacol
January 2025
MOE Key Laboratory for Neuroinformation, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China.
Introduction: Neuroimaging studies have demonstrated that intranasal oxytocin has extensive effects on the resting state functional connectivity of social and emotional processing networks and may have therapeutic potential. However, the extent to which intranasal oxytocin modulates functional connectivity network topology remains less explored, with inconsistent findings in the existing literature. To address this gap, we conducted an exploratory data-driven study.
View Article and Find Full Text PDFCarbohydrate Restriction During Recovery from High-Intensity-Interval Training Enhances Fat Oxidation During Subsequent Exercise and Does Not Compromise Performance When Combined With Caffeine.
Curr Dev Nutr
January 2025
Department for Public Health, Aarhus University, Aarhus, Denmark.
Background: Carbohydrate restriction can alter substrate utilization and potentially impair endurance performance in female athletes. Caffeine intake may mitigate this performance decrements.
Objectives: The aim of this study was to test the hypothesis that maximal fat oxidation (MFO) rate would be enhanced in the carbohydrate (CHO) restricted state in trained females.
Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older women.
Front Nutr
January 2025
Faculty of Health and Life Sciences, Department of Public Health and Sport Sciences, University of Exeter, Exeter, United Kingdom.
Introduction: Shatavari is a herbal dietary supplement that may increase skeletal muscle strength in younger and older adults. Shatavari contains compounds with both estradiol-like and antioxidant properties, which could enhance muscle function. Postmenopausal women may derive the greatest benefit, as estrogen deficiency adversely impacts skeletal muscle function.
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