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Assessment and Reporting of Extraintestinal Manifestations and Fatigue in Phase 3 Inflammatory Bowel Disease Clinical Trials.
J Crohns Colitis
January 2025
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
Background: Extraintestinal Manifestations (EIMs) of Inflammatory Bowel Disease (IBD) are frequently experienced by patients and may lead to severe symptoms and fatigue. However, the reporting patterns of these outcomes in IBD randomized controlled trials (RCTs) is not clear.
Methods: We searched placebo controlled phase 3 RCTs of advanced therapies in IBD and assessed the frequency and means of reporting EIM and fatigue data in these studies.
Shifting Student Attitudes of Gerontology Nursing: A Quasi-Experimental Evaluation of a Clinical Educator Programme.
Int J Older People Nurs
January 2025
School of Nursing, Midwifery and Social Sciences, Central Queensland University, Brisbane, Queensland, Australia.
Background: Enduring shortages in the gerontology nursing workforce are projected to increase as demand for services for older persons grows. Recruitment of Registered Nurses in gerontology is further hindered by negative perceptions held by students towards nursing older people.
Aim: To determine whether a professional development activity designed to assist clinical supervisors to build the mentorship capacity of care staff in residential aged care facilities could positively improve their clinical learning environment and improve student attitudes towards working with older adults.
INTERNATIONAL SYMPOSIUM ON RUMINANT PHYSIOLOGY: Rumen fungi, archaea and their interactions.
J Dairy Sci
January 2025
Laboratory of Gastrointestinal Microbiology, Nanjing Agricultural University, Nanjing, China 210095.
Anaerobic gut fungi (AGF) were the last phylum to be identified within the rumen microbiome and account for 7-9% of microbial biomass. They produce potent lignocellulases that degrade recalcitrant plant cell walls, and rhizoids that can penetrate the cuticle of plant cells, exposing internal components to other microbiota. Interspecies H transfer between AGF and rumen methanogenic archaea is an essential metabolic process in the rumen that occurs during the reduction of CO to CH by methanogens.
View Article and Find Full Text PDFMaintaining first-line therapy plus radiotherapy may prolong progression-free survival and delay second-line therapy for oligoprogressive hepatocellular carcinoma.
Int J Radiat Oncol Biol Phys
January 2025
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.. Electronic address:
Purpose: Optimal treatment strategies for patients with hepatocellular carcinoma (HCC) with oligoprogression after first-line systemic therapy (FLST) remain undefined. We aimed to determine if maintaining [i.e.
View Article and Find Full Text PDFConcentrations and origins of ultrafine particles at a major European harbor.
Sci Total Environ
January 2025
Institute of Environmental Assessment and Water Research, Spanish Research Council (IDÆA-CSIC), c/Jordi Girona 18-26, 08034 Barcelona, Spain.
The maritime transport sector poses significant air quality concerns, particularly in nearby cities. Ultrafine particles (UFP, diameter < 100 nm) are of particular concern due to their potential health impacts. This study measured particle number concentrations (PNC), size distributions (PNSD), and other pollutants including particulate matter (PM), nitrogen oxides (NO), black carbon (BC), sulfur dioxide (SO) and ozone (O), organic markers and trace elements at a major European harbor and an urban background (UB) location.
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