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Reflections on the 2024 Final Rule on Public Health Service Policies on Research Misconduct.
Account Res
January 2025
Department of Philosophy, Georgetown University, Washington, USA.
Background: The Office of Research Integrity (ORI) of the U.S. Department of Health and Human Services (HHS) recently issued the 2024 Final Rule on Public Health Service Policies on Research Misconduct (42 CFR 93), the first major revision of the regulation in nearly twenty years.
View Article and Find Full Text PDFAvoiding never events in orthopaedics theatres: a quality improvement project.
BMJ Open Qual
January 2025
Trauma & Orthopaedics, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
Never events in the operating room are a surgeon's nightmare, with an incidence rate of 54%. These events are highly stressful for theatre staff and significantly compromise patient safety. The aim of this project is to avoid never events in trauma and orthopaedic theatres by ensuring that theatre staff adhere to the surgical pause and imaging pause protocols through regular audits.
View Article and Find Full Text PDFANRORC type rearrangement/intermolecular cyclocondensation cascade of 5,6-dicyano-3-(2-oxo-2-ethyl)pyrazin-2(1)-ones with hydrazine hydrate for the synthesis of 2-(pyrazol-3-yl)imidazo[4,5-]pyridazines.
Org Biomol Chem
January 2025
Mulliken Center for Theoretical Chemistry University of Bonn Beringstr. 4, 53115 Bonn, Germany.
A novel HSO-catalyzed ANRORC-type rearrangement of pyrazinones to imidazoles proceeding through pyridazino[]annulation with simultaneous introduction of a pyrazole ring at position 2 of the imidazole system has been developed, which offers efficient and expedited access to new biheterocyclic systems - 2-(pyrazol-3-ul)imidazoles and 2-(pyrazol-3-yl)imidazo[4,5-]pyridazines. Diverse bi--heterocyclic systems with the imidazo[4,5-]pyridazine-4,7-diamine moiety could be obtained in excellent yield when 5,6-dicyano-3-(2-oxo-2-ethyl)pyrazin-2(1)-ones interact with hydrazines the selective spiro-formation in a tandem ring-opening/ring-closing process, which allowed the simultaneous construction of five new C-N bonds. This new method is compatible with an array of functional groups, proceeds under mild reaction conditions with the involvement of commercially available reagents.
View Article and Find Full Text PDFThe Effectiveness of E-Learning Anticipatory Guidance on Early Childhood Caries among the Mothers of Children Aged 9-24 Months during the Pandemic: A Nonrandomized Controlled Trial.
Int J Clin Pediatr Dent
December 2024
Department of Pediatric and Preventive Dentistry, KVG Dental College and Hospital, Sullia, Karnataka, India.
Background: Early childhood caries (ECC) is a multifactorial disease with known etiologic factors and can be very devastating to the oral and general well-being of a child, including psychological impacts on a growing child. Young children constitute a vulnerable population because of their dependence and inability to communicate their needs. Oral health disparities continue to pose critical challenges, as ECC is the most common chronic disease of childhood.
View Article and Find Full Text PDFFrom past to present: tracing the trends of diabetes drug trials in mainland China.
Front Endocrinol (Lausanne)
January 2025
Department of Pharmacy, Nanjing Gaochun People's Hospital, Nanjing, Jiangsu, China.
Background: This study aimed to analyze the changing trend of diabetes drugs clinical trials in China during 2013-2023, and provided a reference for the research and development of diabetes drugs.
Methods: Diabetes drug clinical trial data were obtained from the registration and information disclosure platform of the National Medical Products Administration (NMPA) between January 1, 2013, and December 31, 2023. Trends of clinical trials on diabetes drugs were systematically analyzed in terms of characteristics, trial design, time trends, drug type, and indications.
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